Uncomplicated stereotactic and open neurosurgical procedures in patients with factor vii deficiency

Stephen E. Doran, Thomas R. Henry, Paula L. Bockenstedt, Donald A. Ross

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Factor VII deficiency is characterized by epistaxis, bruising, hemarthrosis, mennorrhagia, gastrointestinal bleeding, hematuria, and intracranial hemorrhage during infancy. Causes of acquired factor VII deficiency include liver disease, Vitamin K deficiency, and warfarin administration. Congenital factor VII deficiency is an autosomal recessive disorder, with the homozygotes having a severe deficiency and the hetereozygotes a moderate deficiency of factor VII. Orthopedic, gynecological, cardiothoracic, and abdominal surgical procedures have been successfully performed in patients with factor VII deficiency both with and without factor VII replacement. We present two patients with moderate and moderately severe factor VII deficiency who successfully underwent intracranial procedures using plasma during the perioperative period for factor VII replacement. One patient successfully underwent stereotactic placement of mesial temporal lobe depth electrodes and subdural strip electrodes followed by anterior temporal lobectomy for medically refractory seizures. The second patient successfully underwent craniotomy for an olfactory groove meningioma. No bleeding complications were encountered with any of the three intracranial procedures performed. These cases represent the first reported cases of successful intracranial procedures in patients with factor VII deficiency, other than shunting procedures performed for intraventricular hemorrhage during infancy.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalSurgical Neurology
Issue number1
StatePublished - Jul 1994
Externally publishedYes


  • Craniotomy
  • Factor VII deficiency
  • Neurosurgery
  • Stereotactic

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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