TY - JOUR
T1 - Unusual antigen presentation offers new insight into HIV vaccine design
AU - McMichael, Andrew J.
AU - Picker, Louis J.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses.
AB - Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses.
UR - http://www.scopus.com/inward/record.url?scp=85019151038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019151038&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2017.04.009
DO - 10.1016/j.coi.2017.04.009
M3 - Review article
C2 - 28505602
AN - SCOPUS:85019151038
SN - 0952-7915
VL - 46
SP - 75
EP - 81
JO - Current opinion in immunology
JF - Current opinion in immunology
ER -