TY - JOUR
T1 - Unusual Ocular Involvement in Acute Disseminated Histiocytosis X
AU - Lahav, Moshe
AU - Albert, Daniel M.
PY - 1974/6
Y1 - 1974/6
N2 - A white infant was born with acute disseminated histiocytosis X. Clinical ocular examination at birth revealed thickening of the irides with a nodular lesion of the right iris and a focal linear discoloration of the left iris. The pupils showed minimal dilatation following instillation of mydriatics. The child died at 7 days of age; histopathologic examination revealed massive infiltration of histiocytes in the iris, choroid, and meninges of the optic nerve. This pattern of ocular involvement is rare in acute disseminated histiocytosis X. There was involvement by similar cells of the skin, visceral organs, and brain. This association of anterior uveal involvement with severe though clinically unrecognized visceral involvement has been described previously, but not emphasized. Recognition of the ocular involvement may be helpful in the diagnosis, and contribute to the early institution of therapy.
AB - A white infant was born with acute disseminated histiocytosis X. Clinical ocular examination at birth revealed thickening of the irides with a nodular lesion of the right iris and a focal linear discoloration of the left iris. The pupils showed minimal dilatation following instillation of mydriatics. The child died at 7 days of age; histopathologic examination revealed massive infiltration of histiocytes in the iris, choroid, and meninges of the optic nerve. This pattern of ocular involvement is rare in acute disseminated histiocytosis X. There was involvement by similar cells of the skin, visceral organs, and brain. This association of anterior uveal involvement with severe though clinically unrecognized visceral involvement has been described previously, but not emphasized. Recognition of the ocular involvement may be helpful in the diagnosis, and contribute to the early institution of therapy.
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U2 - 10.1001/archopht.1974.03900060469008
DO - 10.1001/archopht.1974.03900060469008
M3 - Article
C2 - 4827431
AN - SCOPUS:0016227893
SN - 0003-9950
VL - 91
SP - 455
EP - 458
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 6
ER -