Update on epidemiology, diagnosis, and disease course of atopic dermatitis

Eric L. Simpson; Alan D. Irvine; Lawrence F. Eichenfield; Sheila F. Friedlander

doi:10.12788/j.sder.2016.041

Update on epidemiology, diagnosis, and disease course of atopic dermatitis

Eric L. Simpson, Alan D. Irvine, Lawrence F. Eichenfield, Sheila F. Friedlander

Dermatology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborns is a strong predictor of AD, regardless of FLG status. Recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of an FLG mutation and concomitant immunoglobulin E sensitization early in life.

Original language	English (US)
Pages (from-to)	84S-88S
Journal	Seminars in cutaneous medicine and surgery
Volume	35
DOIs	https://doi.org/10.12788/j.sder.2016.041
State	Published - Jun 1 2016

Keywords

Atopic dermatitis
Eczema
Filaggrin
Food allergy
Obesity
Peanut allergy
Skin infection

ASJC Scopus subject areas

Surgery
Dermatology

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10.12788/j.sder.2016.041

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title = "Update on epidemiology, diagnosis, and disease course of atopic dermatitis",

abstract = "Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborns is a strong predictor of AD, regardless of FLG status. Recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of an FLG mutation and concomitant immunoglobulin E sensitization early in life.",

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AU - Irvine, Alan D.

AU - Eichenfield, Lawrence F.

AU - Friedlander, Sheila F.

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AB - Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborns is a strong predictor of AD, regardless of FLG status. Recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of an FLG mutation and concomitant immunoglobulin E sensitization early in life.

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KW - Eczema

KW - Filaggrin

KW - Food allergy

KW - Obesity

KW - Peanut allergy

KW - Skin infection

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Update on epidemiology, diagnosis, and disease course of atopic dermatitis

Abstract

Keywords

ASJC Scopus subject areas

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