Update on epidemiology, diagnosis, and disease course of atopic dermatitis

Eric L. Simpson, Alan D. Irvine, Lawrence F. Eichenfield, Sheila F. Friedlander

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborns is a strong predictor of AD, regardless of FLG status. Recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of an FLG mutation and concomitant immunoglobulin E sensitization early in life.

Original languageEnglish (US)
Pages (from-to)84S-88S
JournalSeminars in cutaneous medicine and surgery
StatePublished - Jun 1 2016


  • Atopic dermatitis
  • Eczema
  • Filaggrin
  • Food allergy
  • Obesity
  • Peanut allergy
  • Skin infection

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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