@article{272526e31e2446ffbe715a6432f3181b,
title = "Upper arm anthropometrics versus DXA scan in survivors of acute respiratory distress syndrome",
abstract = "Survivors of acute respiratory distress syndrome (ARDS) experience severe muscle wasting. Upper arm anthropometrics can provide a quick, non-invasive estimate of muscle status, but its accuracy is unknown. This study examines the accuracy of upper arm percent muscle area (UAMA) with reference measures of lean mass from dual energy X-ray absorptiometry (DXA). Data are from 120 ARDS survivors participating in a multicenter national study. Receiver operating characteristic (ROC) curves, by patient sex, demonstrated that UAMA did no better than chance in discriminating low appendicular skeletal muscle mass identified using DXA findings (c-statistics, 6 months: 0.50-0.59, 12 months: 0.54-0.57). Modest correlations of UAMA with DXA measures (whole-body: r = 0.46-0.49, arm-specific: r = 0.50-0.51, p < 0.001) and Bland-Altman plots indicate poor precision. UAMA is not an appropriate screening measure for estimating muscle mass when compared to a DXA reference standard. Alternate screening measures should be evaluated in ARDS survivors.",
author = "Chan, {Kitty S.} and Marina Mourtzakis and {Aronson Friedman}, Lisa and Dinglas, {Victor D.} and Hough, {Catherine L.} and Ely, {E. Wesley} and Morris, {Peter E.} and Hopkins, {Ramona O.} and Needham, {Dale M.}",
note = "Funding Information: Acknowledgements This research was supported by the NHLBI (R24 HL111895, R01HL091760, R01HL091760-02S1, R01HL096504, R01HL88045 and P050HL73994), the Johns Hopkins Institute for Clinical and Translational Research (ICTR) (UL1 TR 000424-06), and the ALTA, EDEN, OMEGA and SAILS trials (contracts for sites participating in this study: HSN268200536170C, HHSN268200536 171C, HHSN268200536173C, HHSN268200536174C, HSN2682005 36175C, and HHSN268200536179C). Funding Information: This research was supported by the NHLBI (R24 HL111895, R01HL091760, R01HL091760-02S1, R01HL096504, R01HL88045 and P050HL73994), the Johns Hopkins Institute for Clinical and Translational Research (ICTR) (UL1 TR 000424-06), and the ALTA, EDEN, OMEGA and SAILS trials (contracts for sites participating in this study: HSN268200536170C, HHSN268200536 171C, HHSN268200536173C, HHSN268200536174C, HSN2682005 36175C, and HHSN268200536179C). Publisher Copyright: {\textcopyright} 2018 Macmillan Publishers Limited, part of Springer Nature.",
year = "2018",
month = apr,
day = "1",
doi = "10.1038/s41430-018-0106-1",
language = "English (US)",
volume = "72",
pages = "613--617",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "Nature Publishing Group",
number = "4",
}