TY - JOUR
T1 - Use of recombinant inbred strains to assess vulnerability to drug abuse at the genetic level
AU - Phillips, Tamara J.
AU - Belknap, John K.
AU - Crabbe, John C.
PY - 1991/4/12
Y1 - 1991/4/12
N2 - The use of Recombinant Inbred mouse Strains (RIS) to derive information about the complexity of the genetic architecture underlying various traits is increasing in popularity. Behaviors measured to index sensitivity to drug effects and vulnerability to drug abuse are considered here. Potential uses of RIS are identification of major gene effects, mapping of traits to particular chromosomal sites, determining genetic correlations between characters, and identifying behaviorally extreme genotypes. This approach has led to identification of a major gene moderating alcohol acceptance in mice and has revealed a more complex polygenic system influencing morphine consumption.
AB - The use of Recombinant Inbred mouse Strains (RIS) to derive information about the complexity of the genetic architecture underlying various traits is increasing in popularity. Behaviors measured to index sensitivity to drug effects and vulnerability to drug abuse are considered here. Potential uses of RIS are identification of major gene effects, mapping of traits to particular chromosomal sites, determining genetic correlations between characters, and identifying behaviorally extreme genotypes. This approach has led to identification of a major gene moderating alcohol acceptance in mice and has revealed a more complex polygenic system influencing morphine consumption.
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U2 - 10.1300/J069v10n01_06
DO - 10.1300/J069v10n01_06
M3 - Article
C2 - 2065120
AN - SCOPUS:0025741758
SN - 1055-0887
VL - 10
SP - 73
EP - 87
JO - Journal of Addictive Diseases
JF - Journal of Addictive Diseases
IS - 1-2
ER -