Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy

Erika L. Finanger; Barry Russman; Sean C. Forbes; William D. Rooney; Glenn A. Walter; Krista Vandenborne

doi:10.1016/j.pmr.2011.11.004

Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy

Erika L. Finanger, Barry Russman, Sean C. Forbes, William D. Rooney, Glenn A. Walter, Krista Vandenborne

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Physical Medicine and Rehabilitation Clinics of North America
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.pmr.2011.11.004
State	Published - Feb 2012

Keywords

Duchenne muscular dystrophy
MRI
Skeletal muscle

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation

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10.1016/j.pmr.2011.11.004

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title = "Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy",

abstract = "Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.",

keywords = "Duchenne muscular dystrophy, MRI, Skeletal muscle",

author = "Finanger, {Erika L.} and Barry Russman and Forbes, {Sean C.} and Rooney, {William D.} and Walter, {Glenn A.} and Krista Vandenborne",

note = "Funding Information: The authors would like to thank the NIH/NIAMS/NINDS for their funding via a multicenter grant ( R01 AR056973 ) which supported this research.",

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T1 - Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy

AU - Finanger, Erika L.

AU - Russman, Barry

AU - Forbes, Sean C.

AU - Rooney, William D.

AU - Walter, Glenn A.

AU - Vandenborne, Krista

N1 - Funding Information: The authors would like to thank the NIH/NIAMS/NINDS for their funding via a multicenter grant ( R01 AR056973 ) which supported this research.

PY - 2012/2

Y1 - 2012/2

N2 - Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.

AB - Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.

KW - Duchenne muscular dystrophy

KW - MRI

KW - Skeletal muscle

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Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy

Abstract

Keywords

ASJC Scopus subject areas

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