Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation

Maud Wang; Hans Henkes; Sherief Ghozy; James E. Siegler; Hamza Shaikh; Jane Khalife; Mohamad Abdalkader; Piers Klein; Thanh N. Nguyen; Jeremy J. Heit; Ahmad Sweid; Kareem El Naamani; Robert W. Regenhardt; Jose Danilo Bengzon Diestro; Nicole M. Cancelliere; Abdelaziz Amllay; Lukas Meyer; Anne Dusart; Flavio Bellante; Géraud Forestier; Aymeric Rouchaud; Suzana Saleme; Charbel Mounayer; Jens Fiehler; Anna Luisa Kühn; Ajit S. Puri; Christian Dyzmann; Peter T. Kan; Marco Colasurdo; Gaultier Marnat; Jérôme Berge; Xavier Barreau; Igor Sibon; Simona Nedelcu; Nils Henninger; Charlotte Weyland; Thomas R. Marotta; Christopher J. Stapleton; James D. Rabinov; Takahiro Ota; Shogo Dofuku; Leonard L.L. Yeo; Benjamin Y.Q. Tan; Juan Carlos Martinez-Gutierrez; Sergio Salazar-Marioni; Sunil Sheth; Leonardo Renieri; Carolina Capirossi; Ashkan Mowla; Stavropoula I. Tjoumakaris; Pascal Jabbour; Priyank Khandelwal; Arundhati Biswas; Frédéric Clarençon; Mahmoud Elhorany; Kevin Premat; Iacopo Valente; Alessandro Pedicelli; João Pedro Filipe; Ricardo Varela; Miguel Quintero-Consuegra; Nestor R. Gonzalez; Markus A. Möhlenbruch; Jessica Jesser; Vincent Costalat; Adrien ter Schiphorst; Vivek Yedavalli; Pablo Harker; Lina M. Chervak; Yasmin Aziz; Benjamin Gory; Christian Paul Stracke; Constantin Hecker; Monika Killer-Oberpfalzer; Christoph J. Griessenauer; Ajith J. Thomas; Cheng Yang Hsieh; David S. Liebeskind; Răzvan Alexandru Radu; Andrea M. Alexandre; Illario Tancredi; Tobias D. Faizy; Aman B. Patel; Vitor Mendes Pereira; Robert Fahed; Boris Lubicz; Adam A. Dmytriw; Adrien Guenego

doi:10.1007/s00234-024-03302-5

Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation

Maud Wang, Hans Henkes, Sherief Ghozy, James E. Siegler, Hamza Shaikh, Jane Khalife, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Jeremy J. Heit, Ahmad Sweid, Kareem El Naamani, Robert W. Regenhardt, Jose Danilo Bengzon Diestro, Nicole M. Cancelliere, Abdelaziz Amllay, Lukas Meyer, Anne Dusart, Flavio Bellante, Géraud ForestierAymeric Rouchaud, Suzana Saleme, Charbel Mounayer, Jens Fiehler, Anna Luisa Kühn, Ajit S. Puri, Christian Dyzmann, Peter T. Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Charlotte Weyland, Thomas R. Marotta, Christopher J. Stapleton, James D. Rabinov, Takahiro Ota, Shogo Dofuku, Leonard L.L. Yeo, Benjamin Y.Q. Tan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Stavropoula I. Tjoumakaris, Pascal Jabbour, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R. Gonzalez, Markus A. Möhlenbruch, Jessica Jesser, Vincent Costalat, Adrien ter Schiphorst, Vivek Yedavalli, Pablo Harker, Lina M. Chervak, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Monika Killer-Oberpfalzer, Christoph J. Griessenauer, Ajith J. Thomas, Cheng Yang Hsieh, David S. Liebeskind, Răzvan Alexandru Radu, Andrea M. Alexandre, Illario Tancredi, Tobias D. Faizy, Aman B. Patel, Vitor Mendes Pereira, Robert Fahed, Boris Lubicz, Adam A. Dmytriw, Adrien Guenego

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Our purpose was to assess the efficacy and safety of the pRESET LITE stent retriever (Phenox, Bochum, Germany), designed for medium vessel occlusion (MeVO) in acute ischemic stroke (AIS) patients with a primary MeVO. Methods: We performed a retrospective analysis of the MAD MT Consortium, an integration of prospectively maintained databases at 37 academic institutions in Europe, North America, and Asia, of AIS patients who underwent mechanical thrombectomy with the pRESET LITE stent retriever for a primary MeVO. We subcategorized occlusions into proximal MeVOs (segments A1, M2, and P1) vs. distal MeVOs/DMVO (segments A2, M3-M4, and P2). We reviewed patient and procedural characteristics, as well as angiographic and clinical outcomes. Results: Between September 2016 and December 2021, 227 patients were included (50% female, median age 78 [65–84] years), of whom 161 (71%) suffered proximal MeVO and 66 (29%) distal MeVO. Using a combined approach in 96% of cases, successful reperfusion of the target vessel (mTICI 2b/2c/3) was attained in 85% of proximal MeVO and 97% of DMVO, with a median of 2 passes (IQR: 1–3) overall. Periprocedural complications rate was 7%. Control CT at day 1 post-MT revealed a hemorrhagic transformation in 63 (39%) patients with proximal MeVO and 24 (36%) patients with DMVO, with ECASS-PH type hemorrhagic transformations occurring in 3 (1%) patients. After 3 months, 58% of all MeVO and 63% of DMVO patients demonstrated a favorable outcome (mRS 0–2). Conclusion: Mechanical thrombectomy using the pRESET LITE in a combined approach with an aspiration catheter appears effective for primary medium vessel occlusions across several centers and physicians.

Original language	English (US)
Pages (from-to)	631-641
Number of pages	11
Journal	Neuroradiology
Volume	66
Issue number	4
DOIs	https://doi.org/10.1007/s00234-024-03302-5
State	Published - Apr 2024
Externally published	Yes

Keywords

Distal thrombectomy
Endovascular recanalization
Medium vessel occlusion
Stent retriever
Stroke

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology
Cardiology and Cardiovascular Medicine

Access to Document

10.1007/s00234-024-03302-5

Cite this

Wang, M., Henkes, H., Ghozy, S., Siegler, J. E., Shaikh, H., Khalife, J., Abdalkader, M., Klein, P., Nguyen, T. N., Heit, J. J., Sweid, A., Naamani, K. E., Regenhardt, R. W., Diestro, J. D. B., Cancelliere, N. M., Amllay, A., Meyer, L., Dusart, A., Bellante, F., ... Guenego, A. (2024). Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation. Neuroradiology, 66(4), 631-641. https://doi.org/10.1007/s00234-024-03302-5

Wang, M, Henkes, H, Ghozy, S, Siegler, JE, Shaikh, H, Khalife, J, Abdalkader, M, Klein, P, Nguyen, TN, Heit, JJ, Sweid, A, Naamani, KE, Regenhardt, RW, Diestro, JDB, Cancelliere, NM, Amllay, A, Meyer, L, Dusart, A, Bellante, F, Forestier, G, Rouchaud, A, Saleme, S, Mounayer, C, Fiehler, J, Kühn, AL, Puri, AS, Dyzmann, C, Kan, PT, Colasurdo, M, Marnat, G, Berge, J, Barreau, X, Sibon, I, Nedelcu, S, Henninger, N, Weyland, C, Marotta, TR, Stapleton, CJ, Rabinov, JD, Ota, T, Dofuku, S, Yeo, LLL, Tan, BYQ, Martinez-Gutierrez, JC, Salazar-Marioni, S, Sheth, S, Renieri, L, Capirossi, C, Mowla, A, Tjoumakaris, SI, Jabbour, P, Khandelwal, P, Biswas, A, Clarençon, F, Elhorany, M, Premat, K, Valente, I, Pedicelli, A, Filipe, JP, Varela, R, Quintero-Consuegra, M, Gonzalez, NR, Möhlenbruch, MA, Jesser, J, Costalat, V, ter Schiphorst, A, Yedavalli, V, Harker, P, Chervak, LM, Aziz, Y, Gory, B, Stracke, CP, Hecker, C, Killer-Oberpfalzer, M, Griessenauer, CJ, Thomas, AJ, Hsieh, CY, Liebeskind, DS, Radu, RA, Alexandre, AM, Tancredi, I, Faizy, TD, Patel, AB, Pereira, VM, Fahed, R, Lubicz, B, Dmytriw, AA & Guenego, A 2024, 'Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation', Neuroradiology, vol. 66, no. 4, pp. 631-641. https://doi.org/10.1007/s00234-024-03302-5

@article{69200adcd5ac4878a869c89aa52405b7,

title = "Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation",

abstract = "Purpose: Our purpose was to assess the efficacy and safety of the pRESET LITE stent retriever (Phenox, Bochum, Germany), designed for medium vessel occlusion (MeVO) in acute ischemic stroke (AIS) patients with a primary MeVO. Methods: We performed a retrospective analysis of the MAD MT Consortium, an integration of prospectively maintained databases at 37 academic institutions in Europe, North America, and Asia, of AIS patients who underwent mechanical thrombectomy with the pRESET LITE stent retriever for a primary MeVO. We subcategorized occlusions into proximal MeVOs (segments A1, M2, and P1) vs. distal MeVOs/DMVO (segments A2, M3-M4, and P2). We reviewed patient and procedural characteristics, as well as angiographic and clinical outcomes. Results: Between September 2016 and December 2021, 227 patients were included (50% female, median age 78 [65–84] years), of whom 161 (71%) suffered proximal MeVO and 66 (29%) distal MeVO. Using a combined approach in 96% of cases, successful reperfusion of the target vessel (mTICI 2b/2c/3) was attained in 85% of proximal MeVO and 97% of DMVO, with a median of 2 passes (IQR: 1–3) overall. Periprocedural complications rate was 7%. Control CT at day 1 post-MT revealed a hemorrhagic transformation in 63 (39%) patients with proximal MeVO and 24 (36%) patients with DMVO, with ECASS-PH type hemorrhagic transformations occurring in 3 (1%) patients. After 3 months, 58% of all MeVO and 63% of DMVO patients demonstrated a favorable outcome (mRS 0–2). Conclusion: Mechanical thrombectomy using the pRESET LITE in a combined approach with an aspiration catheter appears effective for primary medium vessel occlusions across several centers and physicians.",

keywords = "Distal thrombectomy, Endovascular recanalization, Medium vessel occlusion, Stent retriever, Stroke",

author = "Maud Wang and Hans Henkes and Sherief Ghozy and Siegler, {James E.} and Hamza Shaikh and Jane Khalife and Mohamad Abdalkader and Piers Klein and Nguyen, {Thanh N.} and Heit, {Jeremy J.} and Ahmad Sweid and Naamani, {Kareem El} and Regenhardt, {Robert W.} and Diestro, {Jose Danilo Bengzon} and Cancelliere, {Nicole M.} and Abdelaziz Amllay and Lukas Meyer and Anne Dusart and Flavio Bellante and G{\'e}raud Forestier and Aymeric Rouchaud and Suzana Saleme and Charbel Mounayer and Jens Fiehler and K{\"u}hn, {Anna Luisa} and Puri, {Ajit S.} and Christian Dyzmann and Kan, {Peter T.} and Marco Colasurdo and Gaultier Marnat and J{\'e}r{\^o}me Berge and Xavier Barreau and Igor Sibon and Simona Nedelcu and Nils Henninger and Charlotte Weyland and Marotta, {Thomas R.} and Stapleton, {Christopher J.} and Rabinov, {James D.} and Takahiro Ota and Shogo Dofuku and Yeo, {Leonard L.L.} and Tan, {Benjamin Y.Q.} and Martinez-Gutierrez, {Juan Carlos} and Sergio Salazar-Marioni and Sunil Sheth and Leonardo Renieri and Carolina Capirossi and Ashkan Mowla and Tjoumakaris, {Stavropoula I.} and Pascal Jabbour and Priyank Khandelwal and Arundhati Biswas and Fr{\'e}d{\'e}ric Claren{\c c}on and Mahmoud Elhorany and Kevin Premat and Iacopo Valente and Alessandro Pedicelli and Filipe, {Jo{\~a}o Pedro} and Ricardo Varela and Miguel Quintero-Consuegra and Gonzalez, {Nestor R.} and M{\"o}hlenbruch, {Markus A.} and Jessica Jesser and Vincent Costalat and {ter Schiphorst}, Adrien and Vivek Yedavalli and Pablo Harker and Chervak, {Lina M.} and Yasmin Aziz and Benjamin Gory and Stracke, {Christian Paul} and Constantin Hecker and Monika Killer-Oberpfalzer and Griessenauer, {Christoph J.} and Thomas, {Ajith J.} and Hsieh, {Cheng Yang} and Liebeskind, {David S.} and Radu, {R{\u a}zvan Alexandru} and Alexandre, {Andrea M.} and Illario Tancredi and Faizy, {Tobias D.} and Patel, {Aman B.} and Pereira, {Vitor Mendes} and Robert Fahed and Boris Lubicz and Dmytriw, {Adam A.} and Adrien Guenego",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.",

year = "2024",

month = apr,

doi = "10.1007/s00234-024-03302-5",

language = "English (US)",

volume = "66",

pages = "631--641",

journal = "Neuroradiology",

issn = "0028-3940",

publisher = "Springer Verlag",

number = "4",

}

TY - JOUR

T1 - Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions

T2 - A multicenter evaluation

AU - Wang, Maud

AU - Henkes, Hans

AU - Ghozy, Sherief

AU - Siegler, James E.

AU - Shaikh, Hamza

AU - Khalife, Jane

AU - Abdalkader, Mohamad

AU - Klein, Piers

AU - Nguyen, Thanh N.

AU - Heit, Jeremy J.

AU - Sweid, Ahmad

AU - Naamani, Kareem El

AU - Regenhardt, Robert W.

AU - Diestro, Jose Danilo Bengzon

AU - Cancelliere, Nicole M.

AU - Amllay, Abdelaziz

AU - Meyer, Lukas

AU - Dusart, Anne

AU - Bellante, Flavio

AU - Forestier, Géraud

AU - Rouchaud, Aymeric

AU - Saleme, Suzana

AU - Mounayer, Charbel

AU - Fiehler, Jens

AU - Kühn, Anna Luisa

AU - Puri, Ajit S.

AU - Dyzmann, Christian

AU - Kan, Peter T.

AU - Colasurdo, Marco

AU - Marnat, Gaultier

AU - Berge, Jérôme

AU - Barreau, Xavier

AU - Sibon, Igor

AU - Nedelcu, Simona

AU - Henninger, Nils

AU - Weyland, Charlotte

AU - Marotta, Thomas R.

AU - Stapleton, Christopher J.

AU - Rabinov, James D.

AU - Ota, Takahiro

AU - Dofuku, Shogo

AU - Yeo, Leonard L.L.

AU - Tan, Benjamin Y.Q.

AU - Martinez-Gutierrez, Juan Carlos

AU - Salazar-Marioni, Sergio

AU - Sheth, Sunil

AU - Renieri, Leonardo

AU - Capirossi, Carolina

AU - Mowla, Ashkan

AU - Tjoumakaris, Stavropoula I.

AU - Jabbour, Pascal

AU - Khandelwal, Priyank

AU - Biswas, Arundhati

AU - Clarençon, Frédéric

AU - Elhorany, Mahmoud

AU - Premat, Kevin

AU - Valente, Iacopo

AU - Pedicelli, Alessandro

AU - Filipe, João Pedro

AU - Varela, Ricardo

AU - Quintero-Consuegra, Miguel

AU - Gonzalez, Nestor R.

AU - Möhlenbruch, Markus A.

AU - Jesser, Jessica

AU - Costalat, Vincent

AU - ter Schiphorst, Adrien

AU - Yedavalli, Vivek

AU - Harker, Pablo

AU - Chervak, Lina M.

AU - Aziz, Yasmin

AU - Gory, Benjamin

AU - Stracke, Christian Paul

AU - Hecker, Constantin

AU - Killer-Oberpfalzer, Monika

AU - Griessenauer, Christoph J.

AU - Thomas, Ajith J.

AU - Hsieh, Cheng Yang

AU - Liebeskind, David S.

AU - Radu, Răzvan Alexandru

AU - Alexandre, Andrea M.

AU - Tancredi, Illario

AU - Faizy, Tobias D.

AU - Patel, Aman B.

AU - Pereira, Vitor Mendes

AU - Fahed, Robert

AU - Lubicz, Boris

AU - Dmytriw, Adam A.

AU - Guenego, Adrien

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

PY - 2024/4

Y1 - 2024/4

N2 - Purpose: Our purpose was to assess the efficacy and safety of the pRESET LITE stent retriever (Phenox, Bochum, Germany), designed for medium vessel occlusion (MeVO) in acute ischemic stroke (AIS) patients with a primary MeVO. Methods: We performed a retrospective analysis of the MAD MT Consortium, an integration of prospectively maintained databases at 37 academic institutions in Europe, North America, and Asia, of AIS patients who underwent mechanical thrombectomy with the pRESET LITE stent retriever for a primary MeVO. We subcategorized occlusions into proximal MeVOs (segments A1, M2, and P1) vs. distal MeVOs/DMVO (segments A2, M3-M4, and P2). We reviewed patient and procedural characteristics, as well as angiographic and clinical outcomes. Results: Between September 2016 and December 2021, 227 patients were included (50% female, median age 78 [65–84] years), of whom 161 (71%) suffered proximal MeVO and 66 (29%) distal MeVO. Using a combined approach in 96% of cases, successful reperfusion of the target vessel (mTICI 2b/2c/3) was attained in 85% of proximal MeVO and 97% of DMVO, with a median of 2 passes (IQR: 1–3) overall. Periprocedural complications rate was 7%. Control CT at day 1 post-MT revealed a hemorrhagic transformation in 63 (39%) patients with proximal MeVO and 24 (36%) patients with DMVO, with ECASS-PH type hemorrhagic transformations occurring in 3 (1%) patients. After 3 months, 58% of all MeVO and 63% of DMVO patients demonstrated a favorable outcome (mRS 0–2). Conclusion: Mechanical thrombectomy using the pRESET LITE in a combined approach with an aspiration catheter appears effective for primary medium vessel occlusions across several centers and physicians.

AB - Purpose: Our purpose was to assess the efficacy and safety of the pRESET LITE stent retriever (Phenox, Bochum, Germany), designed for medium vessel occlusion (MeVO) in acute ischemic stroke (AIS) patients with a primary MeVO. Methods: We performed a retrospective analysis of the MAD MT Consortium, an integration of prospectively maintained databases at 37 academic institutions in Europe, North America, and Asia, of AIS patients who underwent mechanical thrombectomy with the pRESET LITE stent retriever for a primary MeVO. We subcategorized occlusions into proximal MeVOs (segments A1, M2, and P1) vs. distal MeVOs/DMVO (segments A2, M3-M4, and P2). We reviewed patient and procedural characteristics, as well as angiographic and clinical outcomes. Results: Between September 2016 and December 2021, 227 patients were included (50% female, median age 78 [65–84] years), of whom 161 (71%) suffered proximal MeVO and 66 (29%) distal MeVO. Using a combined approach in 96% of cases, successful reperfusion of the target vessel (mTICI 2b/2c/3) was attained in 85% of proximal MeVO and 97% of DMVO, with a median of 2 passes (IQR: 1–3) overall. Periprocedural complications rate was 7%. Control CT at day 1 post-MT revealed a hemorrhagic transformation in 63 (39%) patients with proximal MeVO and 24 (36%) patients with DMVO, with ECASS-PH type hemorrhagic transformations occurring in 3 (1%) patients. After 3 months, 58% of all MeVO and 63% of DMVO patients demonstrated a favorable outcome (mRS 0–2). Conclusion: Mechanical thrombectomy using the pRESET LITE in a combined approach with an aspiration catheter appears effective for primary medium vessel occlusions across several centers and physicians.

KW - Distal thrombectomy

KW - Endovascular recanalization

KW - Medium vessel occlusion

KW - Stent retriever

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=85185904241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85185904241&partnerID=8YFLogxK

U2 - 10.1007/s00234-024-03302-5

DO - 10.1007/s00234-024-03302-5

M3 - Article

C2 - 38381145

AN - SCOPUS:85185904241

SN - 0028-3940

VL - 66

SP - 631

EP - 641

JO - Neuroradiology

JF - Neuroradiology

IS - 4

ER -

Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this