Abstract
Pathway databases provide descriptions of the roles of proteins, nucleic acids, lipids, carbohydrates, and other molecular entities within their biological cellular contexts. Pathway-centric views of these roles may allow for the discovery of unexpected functional relationships in data such as gene expression profiles and somatic mutation catalogues from tumor cells. For this reason, there is a high demand for high-quality pathway databases and their associated tools. The Reactome project (a collaboration between the Ontario Institute for Cancer Research, New York University Langone Health, the European Bioinformatics Institute, and Oregon Health & Science University) is one such pathway database. Reactome collects detailed information on biological pathways and processes in humans from the primary literature. Reactome content is manually curated, expert-authored, and peer-reviewed and spans the gamut from simple intermediate metabolism to signaling pathways and complex cellular events. This information is supplemented with likely orthologous molecular reactions in mouse, rat, zebrafish, worm, and other model organisms.
Original language | English (US) |
---|---|
Article number | e722 |
Journal | Current Protocols |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2023 |
Keywords
- Reactome database
- biological pathway
- interaction network
- pathway analysis
- pathway visualization
ASJC Scopus subject areas
- General Immunology and Microbiology
- General Pharmacology, Toxicology and Pharmaceutics
- Medical Laboratory Technology
- General Biochemistry, Genetics and Molecular Biology
- Health Informatics
- General Neuroscience