Uterine oxygen uptake in the pregnant pygmy goat

John M. Bissonnette; James Metcalfe; A. Roger Hohimer; Martin L. Pernoll; J. Eugen Welch; Maralee S. Lawson

doi:10.1016/0034-5687(80)90126-7

Uterine oxygen uptake in the pregnant pygmy goat

John M. Bissonnette, James Metcalfe, A. Roger Hohimer, Martin L. Pernoll, J. Eugen Welch, Maralee S. Lawson

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The diffusion equilibrium method was used to measure uterine blood flow (Q̇ut) and oxygen consumption (V̇utO₂) of 7 Pygmy goats in the last third of pregnancy. V̇utO₂ was 9.3 ± 1.3 (mean ± SEM) ml · min^-1 · kg^-1 weight of the uterus and its contents: the placenta, fetus and fetal membranes. This O₂ requirement was provided by a high blood flow (349 ± 48 ml · min^-1 · kg^-1) and a narrow arteriovenous difference (2.4 ± 0.1 vol %) across the uterus. Maternal arterial O₂ content (Ca_O₂) was varied by incurring chronic anemia in 3 animals. Ca_O₂ over the range 6.5-12.8 vol % did not affect uterine blood flow or the arteriovenous oxygen content difference across the uterus. Weight specific (ml · min^-1 · kg^-1) V̇ut_O₂ did not differ in animals whose total uterine weights varied over a wide range and uterine vein oxygen tension and content did not fall prior to delivery. We conclude that the absolute uterine blood flow varies over a wide range to meet the requirements of the uterine contents.

Original language	English (US)
Pages (from-to)	373-381
Number of pages	9
Journal	Respiration Physiology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1016/0034-5687(80)90126-7
State	Published - Dec 1980

Keywords

Anemia
Fetus
Oxygen consumption
Placenta
Pregnancy
Uterine blood flow

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

Access to Document

10.1016/0034-5687(80)90126-7

Cite this

@article{aa19bc8a6b2a4ebdb4e115884986b010,

title = "Uterine oxygen uptake in the pregnant pygmy goat",

abstract = "The diffusion equilibrium method was used to measure uterine blood flow ({\.Q}ut) and oxygen consumption ({\.V}utO2) of 7 Pygmy goats in the last third of pregnancy. {\.V}utO2 was 9.3 ± 1.3 (mean ± SEM) ml · min-1 · kg-1 weight of the uterus and its contents: the placenta, fetus and fetal membranes. This O2 requirement was provided by a high blood flow (349 ± 48 ml · min-1 · kg-1) and a narrow arteriovenous difference (2.4 ± 0.1 vol %) across the uterus. Maternal arterial O2 content (CaO2 ) was varied by incurring chronic anemia in 3 animals. CaO2 over the range 6.5-12.8 vol % did not affect uterine blood flow or the arteriovenous oxygen content difference across the uterus. Weight specific (ml · min-1 · kg-1) {\.V}utO2 did not differ in animals whose total uterine weights varied over a wide range and uterine vein oxygen tension and content did not fall prior to delivery. We conclude that the absolute uterine blood flow varies over a wide range to meet the requirements of the uterine contents.",

keywords = "Anemia, Fetus, Oxygen consumption, Placenta, Pregnancy, Uterine blood flow",

author = "Bissonnette, {John M.} and James Metcalfe and Hohimer, {A. Roger} and Pernoll, {Martin L.} and Welch, {J. Eugen} and Lawson, {Maralee S.}",

note = "Funding Information: * This work was supported by U.S. Public Health Services Grant No. P01 HD 10034 and by the Oregon Heart Association. i j.M. Bissonnette is recipient of U.S. Public Health Service Research Career Development Award No. K04 HD 00139.",

year = "1980",

month = dec,

doi = "10.1016/0034-5687(80)90126-7",

language = "English (US)",

volume = "42",

pages = "373--381",

journal = "Respiration Physiology",

issn = "0034-5687",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Uterine oxygen uptake in the pregnant pygmy goat

AU - Bissonnette, John M.

AU - Metcalfe, James

AU - Hohimer, A. Roger

AU - Pernoll, Martin L.

AU - Welch, J. Eugen

AU - Lawson, Maralee S.

N1 - Funding Information: * This work was supported by U.S. Public Health Services Grant No. P01 HD 10034 and by the Oregon Heart Association. i j.M. Bissonnette is recipient of U.S. Public Health Service Research Career Development Award No. K04 HD 00139.

PY - 1980/12

Y1 - 1980/12

N2 - The diffusion equilibrium method was used to measure uterine blood flow (Q̇ut) and oxygen consumption (V̇utO2) of 7 Pygmy goats in the last third of pregnancy. V̇utO2 was 9.3 ± 1.3 (mean ± SEM) ml · min-1 · kg-1 weight of the uterus and its contents: the placenta, fetus and fetal membranes. This O2 requirement was provided by a high blood flow (349 ± 48 ml · min-1 · kg-1) and a narrow arteriovenous difference (2.4 ± 0.1 vol %) across the uterus. Maternal arterial O2 content (CaO2 ) was varied by incurring chronic anemia in 3 animals. CaO2 over the range 6.5-12.8 vol % did not affect uterine blood flow or the arteriovenous oxygen content difference across the uterus. Weight specific (ml · min-1 · kg-1) V̇utO2 did not differ in animals whose total uterine weights varied over a wide range and uterine vein oxygen tension and content did not fall prior to delivery. We conclude that the absolute uterine blood flow varies over a wide range to meet the requirements of the uterine contents.

AB - The diffusion equilibrium method was used to measure uterine blood flow (Q̇ut) and oxygen consumption (V̇utO2) of 7 Pygmy goats in the last third of pregnancy. V̇utO2 was 9.3 ± 1.3 (mean ± SEM) ml · min-1 · kg-1 weight of the uterus and its contents: the placenta, fetus and fetal membranes. This O2 requirement was provided by a high blood flow (349 ± 48 ml · min-1 · kg-1) and a narrow arteriovenous difference (2.4 ± 0.1 vol %) across the uterus. Maternal arterial O2 content (CaO2 ) was varied by incurring chronic anemia in 3 animals. CaO2 over the range 6.5-12.8 vol % did not affect uterine blood flow or the arteriovenous oxygen content difference across the uterus. Weight specific (ml · min-1 · kg-1) V̇utO2 did not differ in animals whose total uterine weights varied over a wide range and uterine vein oxygen tension and content did not fall prior to delivery. We conclude that the absolute uterine blood flow varies over a wide range to meet the requirements of the uterine contents.

KW - Anemia

KW - Fetus

KW - Oxygen consumption

KW - Placenta

KW - Pregnancy

KW - Uterine blood flow

UR - http://www.scopus.com/inward/record.url?scp=0019192807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019192807&partnerID=8YFLogxK

U2 - 10.1016/0034-5687(80)90126-7

DO - 10.1016/0034-5687(80)90126-7

M3 - Article

C2 - 7221224

AN - SCOPUS:0019192807

SN - 0034-5687

VL - 42

SP - 373

EP - 381

JO - Respiration Physiology

JF - Respiration Physiology

IS - 3

ER -

Uterine oxygen uptake in the pregnant pygmy goat

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this