The availability and diversity of mouse models of human cancer that develop organ-specific neoplasms has increased significantly in the past 10 years. These, coupled with mouse strains where components of the immune system have been manipulated or deleted, have provided novel insights into how immune cells and immune function significantly contributes to cancer development. Herein, we review relevant literature, where mouse models of human cancer development have provided novel insights into mechanisms of pro- versus antitumor immunity.
|Original language||English (US)|
|Title of host publication||Genetically Engineered Mice for Cancer Research|
|Subtitle of host publication||Design, Analysis, Pathways, Validation and Pre-Clinical Testing|
|Publisher||Springer New York|
|Number of pages||21|
|State||Published - Jan 1 2012|
ASJC Scopus subject areas