Vaginal ring delivery of selective progesterone receptor modulators for contraception

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Vaginal ring delivery of selective progesterone receptor modulators (SPRMs) is under development to address the limitations of current hormonal methods that affect use and effectiveness. This method would be appropriate for use in women with contraindications to, or preferences to avoid, estrogens. A contraceptive vaginal ring (CVR) also eliminates the need for daily dosing and therefore might improve the effectiveness of contraception. The principal contraceptive effect of SPRMs is the suppression of ovulation. One limiting factor of chronic SPRM administration is the development of benign endometrial thickening characterized as PRM-associated endometrial changes. Ulipristal acetate (UPA) is approved for use as an emergency contraceptive pill, but no SPRM is approved for regular contraception. The Population Council is developing an ulipristal acetate CVR for regular contraception. The CVR studied is of a matrix design composed of micronized UPA mixed in a silicone rubber matrix The target product is a ring designed for continuous use over 3 months delivering near steady-state drug levels that will suppress ovulation. Results from Phase 1 and 2 studies demonstrate that suppression of ovulation occurs with UPA levels above 6-7 ng/mL.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
Issue number3
StatePublished - Mar 2013


  • Contraceptive
  • Ovulation
  • Progesterone-receptor modulator
  • Suppression
  • Ulipristal
  • Vaginal ring

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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