TY - JOUR
T1 - Validation of the Myocardial Performance Index by Echocardiography in Mice
T2 - A Noninvasive Measure of Left Ventricular Function
AU - Broberg, Craig S.
AU - Pantely, George A.
AU - Barber, Brent J.
AU - Mack, Gordon K.
AU - Lee, Kathryn
AU - Thigpen, Timothy
AU - Davis, Lowell E.
AU - Sahn, David
AU - Hohimer, A. Roger
N1 - Funding Information:
Supported by an American Heart Association Research Fellowship Grants R03HD38495 and 5R01HL45043.
PY - 2003/8
Y1 - 2003/8
N2 - Background: The myocardial performance index (MPI) is a Doppler-based measure of left ventricular (LV) function. It is noninvasive, independent of LV shape, and does not require dimensional measurements. However, it has never been validated in mice. Methods: A total of 29 anesthetized mice with IV pressure catheters underwent echocardiography (2-dimensional, M-mode, and Doppler) at baseline and during manipulations of β-adrenergic tone, temperature, preload, and afterload. The maximum derivative of LV pressure with respect to time (dP/dtmax) was compared with MPI, fractional shortening (FS), mean velocity of circumferential fiber shortening, and the FS/MPI ratio. Results: MPI (baseline 0.44 ± 0.07) correlated strongly with dP/dtmax (R = -.779, P × .001), as did FS and mean velocity of circumferential fiber shortening. MPI differed significantly with contractility, preload, and afterload manipulation. FS/MPI showed the best correlation with dP/dtmax. Conclusions: MPI strongly correlates with dP/dtmax over a range of hemodynamic conditions in mice. It can be used as a noninvasive index of LV function in this species.
AB - Background: The myocardial performance index (MPI) is a Doppler-based measure of left ventricular (LV) function. It is noninvasive, independent of LV shape, and does not require dimensional measurements. However, it has never been validated in mice. Methods: A total of 29 anesthetized mice with IV pressure catheters underwent echocardiography (2-dimensional, M-mode, and Doppler) at baseline and during manipulations of β-adrenergic tone, temperature, preload, and afterload. The maximum derivative of LV pressure with respect to time (dP/dtmax) was compared with MPI, fractional shortening (FS), mean velocity of circumferential fiber shortening, and the FS/MPI ratio. Results: MPI (baseline 0.44 ± 0.07) correlated strongly with dP/dtmax (R = -.779, P × .001), as did FS and mean velocity of circumferential fiber shortening. MPI differed significantly with contractility, preload, and afterload manipulation. FS/MPI showed the best correlation with dP/dtmax. Conclusions: MPI strongly correlates with dP/dtmax over a range of hemodynamic conditions in mice. It can be used as a noninvasive index of LV function in this species.
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U2 - 10.1067/S0894-7317(03)00399-7
DO - 10.1067/S0894-7317(03)00399-7
M3 - Article
C2 - 12878990
AN - SCOPUS:0242720359
SN - 0894-7317
VL - 16
SP - 814
EP - 823
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 8
ER -