Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia

Bonnie K. Dwyer, Sacha Krieg, Raymond Balise, Ian R. Carroll, Jane Chueh, Nihar Nayak, Maurice Druzin

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Objective.To explore angiogenic factor differences in preeclamptic patients according to the absence or presence of underlying vascular disease. Methods.We prospectively compared serum soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) from 41 normal-risk and 32 high-risk (preexisting conditions) subjects at serial gestational ages. Results.Median sFlt1 was lower at delivery in preeclamptic patients with underlying chronic hypertension and/or chronic proteinuria (5115pg/ml) compared with normal risk preeclamptic patients (16375pg/ml). PlGF was consistently low in patients who developed preeclampsia. Conclusions.Effects of sFlt1 may be contextual, varying according to the health or disease state of vascular endothelium.

Original languageEnglish (US)
Pages (from-to)705-711
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number7
StatePublished - Jul 2010
Externally publishedYes


  • High risk pregnancy
  • Hypertension
  • Placental growth factor
  • Preeclampsia
  • Proteinuria
  • Soluble endoglin
  • Soluble fms-like tyrosine kinase 1

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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