Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)

S. Chinn; P. Burney; D. Jarvis; C. Luczynska; E. Lai; P. Burney; S. Chinn; C. Luczynska; D. Jarvis; P. Vermeire; H. Kesteloot; J. Bousquet; J. Bousquet; J. Knani; D. Nowak; H. Magnussen; J. Prichard; S. Allwright; D. MacLeod; R. de Marco; R. de Marco Lo Cascio; C. Campello; B. Rijcken; J. M. Antó; J. Sunyer; F. Burgos; J. Castellsagué; J. Roca; J. B. Soriano; A. Tobías; J. Alves; J. A. Marques; G. Boman; C. Janson; E. Björnsson; N. Nielsen; P. Paoletti; W. Popp; M. Abramson; J. Kutin; P. Vermeire; F. van Bastelaer; F. Neukirch; R. Liard; I. Pin; C. Pison; A. Taytard; H. E. Wichmann; J. Heinrich; N. Papageorgiou; P. Avarlis; M. Gaga; C. Marossis; T. Gislason; D. Gislason; M. Bugiani; C. Bucca; C. Romano; A. Marinoni; T. Cerveri; L. Casali; A. Kremer; J. Crane; S. Lewis; A. Gulsvik; E. Omenaas; N. Muniozguren; J. Ramos González; A. Capelastegui; J. Castillo; J. Rodriguez Portal; J. Martinez-Moratalla; E. Almar; J. Maldonado Pérez; A. Pereira; J. Sánchez; J. Quiros; I. Huerta; F. Pavo; L. Rosenhall; E. Norrman; B. Lundbäck; N. Lindholm; P. Plaschke; U. Ackermann-Liebrich; N. Künzli; A. Perruchoud; M. Burr; J. Layzell; R. Hall; B. Harrison; J. Stark; S. Buist; W. Vollmer; Molly Osborne

doi:10.1183/09031936.97.10112495

Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)

S. Chinn, P. Burney, D. Jarvis, C. Luczynska, E. Lai, P. Burney, S. Chinn, C. Luczynska, D. Jarvis, P. Vermeire, H. Kesteloot, J. Bousquet, J. Bousquet, J. Knani, D. Nowak, H. Magnussen, J. Prichard, S. Allwright, D. MacLeod, R. de MarcoR. de Marco Lo Cascio, C. Campello, B. Rijcken, J. M. Antó, J. Sunyer, F. Burgos, J. Castellsagué, J. Roca, J. B. Soriano, A. Tobías, J. Alves, J. A. Marques, G. Boman, C. Janson, E. Björnsson, N. Nielsen, P. Paoletti, W. Popp, M. Abramson, J. Kutin, P. Vermeire, F. van Bastelaer, F. Neukirch, R. Liard, I. Pin, C. Pison, A. Taytard, H. E. Wichmann, J. Heinrich, N. Papageorgiou, P. Avarlis, M. Gaga, C. Marossis, T. Gislason, D. Gislason, M. Bugiani, C. Bucca, C. Romano, A. Marinoni, T. Cerveri, L. Casali, A. Kremer, J. Crane, S. Lewis, A. Gulsvik, E. Omenaas, N. Muniozguren, J. Ramos González, A. Capelastegui, J. Castillo, J. Rodriguez Portal, J. Martinez-Moratalla, E. Almar, J. Maldonado Pérez, A. Pereira, J. Sánchez, J. Quiros, I. Huerta, F. Pavo, L. Rosenhall, E. Norrman, B. Lundbäck, N. Lindholm, P. Plaschke, U. Ackermann-Liebrich, N. Künzli, A. Perruchoud, M. Burr, J. Layzell, R. Hall, B. Harrison, J. Stark, S. Buist, W. Vollmer, Molly Osborne

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

175 Scopus citations

Abstract

Attempts to compare bronchial responsiveness between populations have been hampered by between-study differences in the pharmacological agent of provocation, the method of administration and the summary statistic employed. The European Community Respiratory Health Survey used methacholine challenge delivered by Mefar dosimeter according to a standardized protocol used in 35 centres in 16 countries. Data were obtained from 13,161 men and women, aged 20-44 yrs at the start of the study. The dose of methacholine producing a 20% fall in forced expiratory volume in one second (FEV1) (PD20) and the regression coefficient of percentage decline in FEV1 with log dose, were calculated ('slope', after transformation), with and without calibration of nebulizers by weight and adjustment for nonresponsc bias. Standardization for baseline lung function and variation in smoking prevalence was applied to slope. Results were robust to whichever summary measure was used, and to the various adjustments. Responsiveness was low in Iceland and Switzerland, and in most centres in Sweden, Italy and Spain, and high in New Zealand, Australia, the USA, Britain, France, Denmark and Germany. Bronchial responsiveness varies considerably in Europe, and high levels are not confined to the English-speaking world.

Original language	English (US)
Pages (from-to)	2495-2501
Number of pages	7
Journal	European Respiratory Journal
Volume	10
Issue number	11
DOIs	https://doi.org/10.1183/09031936.97.10112495
State	Published - Nov 1997

Keywords

Bronchial provocation tests
Epidemiology
Methacholine
Multi-centre study

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/09031936.97.10112495

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Chinn, S., Burney, P., Jarvis, D., Luczynska, C., Lai, E., Burney, P., Chinn, S., Luczynska, C., Jarvis, D., Vermeire, P., Kesteloot, H., Bousquet, J., Bousquet, J., Knani, J., Nowak, D., Magnussen, H., Prichard, J., Allwright, S., MacLeod, D., ... Osborne, M. (1997). Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS). European Respiratory Journal, 10(11), 2495-2501. https://doi.org/10.1183/09031936.97.10112495

Chinn, S, Burney, P, Jarvis, D, Luczynska, C, Lai, E, Burney, P, Chinn, S, Luczynska, C, Jarvis, D, Vermeire, P, Kesteloot, H, Bousquet, J, Bousquet, J, Knani, J, Nowak, D, Magnussen, H, Prichard, J, Allwright, S, MacLeod, D, de Marco, R, Lo Cascio, RDM, Campello, C, Rijcken, B, Antó, JM, Sunyer, J, Burgos, F, Castellsagué, J, Roca, J, Soriano, JB, Tobías, A, Alves, J, Marques, JA, Boman, G, Janson, C, Björnsson, E, Nielsen, N, Paoletti, P, Popp, W, Abramson, M, Kutin, J, Vermeire, P, van Bastelaer, F, Neukirch, F, Liard, R, Pin, I, Pison, C, Taytard, A, Wichmann, HE, Heinrich, J, Papageorgiou, N, Avarlis, P, Gaga, M, Marossis, C, Gislason, T, Gislason, D, Bugiani, M, Bucca, C, Romano, C, Marinoni, A, Cerveri, T, Casali, L, Kremer, A, Crane, J, Lewis, S, Gulsvik, A, Omenaas, E, Muniozguren, N, Ramos González, J, Capelastegui, A, Castillo, J, Rodriguez Portal, J, Martinez-Moratalla, J, Almar, E, Maldonado Pérez, J, Pereira, A, Sánchez, J, Quiros, J, Huerta, I, Pavo, F, Rosenhall, L, Norrman, E, Lundbäck, B, Lindholm, N, Plaschke, P, Ackermann-Liebrich, U, Künzli, N, Perruchoud, A, Burr, M, Layzell, J, Hall, R, Harrison, B, Stark, J, Buist, S, Vollmer, W & Osborne, M 1997, 'Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)', European Respiratory Journal, vol. 10, no. 11, pp. 2495-2501. https://doi.org/10.1183/09031936.97.10112495

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title = "Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)",

abstract = "Attempts to compare bronchial responsiveness between populations have been hampered by between-study differences in the pharmacological agent of provocation, the method of administration and the summary statistic employed. The European Community Respiratory Health Survey used methacholine challenge delivered by Mefar dosimeter according to a standardized protocol used in 35 centres in 16 countries. Data were obtained from 13,161 men and women, aged 20-44 yrs at the start of the study. The dose of methacholine producing a 20% fall in forced expiratory volume in one second (FEV1) (PD20) and the regression coefficient of percentage decline in FEV1 with log dose, were calculated ('slope', after transformation), with and without calibration of nebulizers by weight and adjustment for nonresponsc bias. Standardization for baseline lung function and variation in smoking prevalence was applied to slope. Results were robust to whichever summary measure was used, and to the various adjustments. Responsiveness was low in Iceland and Switzerland, and in most centres in Sweden, Italy and Spain, and high in New Zealand, Australia, the USA, Britain, France, Denmark and Germany. Bronchial responsiveness varies considerably in Europe, and high levels are not confined to the English-speaking world.",

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author = "S. Chinn and P. Burney and D. Jarvis and C. Luczynska and E. Lai and P. Burney and S. Chinn and C. Luczynska and D. Jarvis and P. Vermeire and H. Kesteloot and J. Bousquet and J. Bousquet and J. Knani and D. Nowak and H. Magnussen and J. Prichard and S. Allwright and D. MacLeod and {de Marco}, R. and {Lo Cascio}, {R. de Marco} and C. Campello and B. Rijcken and Ant{\'o}, {J. M.} and J. Sunyer and F. Burgos and J. Castellsagu{\'e} and J. Roca and Soriano, {J. B.} and A. Tob{\'i}as and J. Alves and Marques, {J. A.} and G. Boman and C. Janson and E. Bj{\"o}rnsson and N. Nielsen and P. Paoletti and W. Popp and M. Abramson and J. Kutin and P. Vermeire and {van Bastelaer}, F. and F. Neukirch and R. Liard and I. Pin and C. Pison and A. Taytard and Wichmann, {H. E.} and J. Heinrich and N. Papageorgiou and P. Avarlis and M. Gaga and C. Marossis and T. Gislason and D. Gislason and M. Bugiani and C. Bucca and C. Romano and A. Marinoni and T. Cerveri and L. Casali and A. Kremer and J. Crane and S. Lewis and A. Gulsvik and E. Omenaas and N. Muniozguren and {Ramos Gonz{\'a}lez}, J. and A. Capelastegui and J. Castillo and {Rodriguez Portal}, J. and J. Martinez-Moratalla and E. Almar and {Maldonado P{\'e}rez}, J. and A. Pereira and J. S{\'a}nchez and J. Quiros and I. Huerta and F. Pavo and L. Rosenhall and E. Norrman and B. Lundb{\"a}ck and N. Lindholm and P. Plaschke and U. Ackermann-Liebrich and N. K{\"u}nzli and A. Perruchoud and M. Burr and J. Layzell and R. Hall and B. Harrison and J. Stark and S. Buist and W. Vollmer and Molly Osborne",

year = "1997",

month = nov,

doi = "10.1183/09031936.97.10112495",

language = "English (US)",

volume = "10",

pages = "2495--2501",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "11",

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TY - JOUR

T1 - Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)

AU - Chinn, S.

AU - Burney, P.

AU - Jarvis, D.

AU - Luczynska, C.

AU - Lai, E.

AU - Burney, P.

AU - Chinn, S.

AU - Luczynska, C.

AU - Jarvis, D.

AU - Vermeire, P.

AU - Kesteloot, H.

AU - Bousquet, J.

AU - Knani, J.

AU - Nowak, D.

AU - Magnussen, H.

AU - Prichard, J.

AU - Allwright, S.

AU - MacLeod, D.

AU - de Marco, R.

AU - Lo Cascio, R. de Marco

AU - Campello, C.

AU - Rijcken, B.

AU - Antó, J. M.

AU - Sunyer, J.

AU - Burgos, F.

AU - Castellsagué, J.

AU - Roca, J.

AU - Soriano, J. B.

AU - Tobías, A.

AU - Alves, J.

AU - Marques, J. A.

AU - Boman, G.

AU - Janson, C.

AU - Björnsson, E.

AU - Nielsen, N.

AU - Paoletti, P.

AU - Popp, W.

AU - Abramson, M.

AU - Kutin, J.

AU - Vermeire, P.

AU - van Bastelaer, F.

AU - Neukirch, F.

AU - Liard, R.

AU - Pin, I.

AU - Pison, C.

AU - Taytard, A.

AU - Wichmann, H. E.

AU - Heinrich, J.

AU - Papageorgiou, N.

AU - Avarlis, P.

AU - Gaga, M.

AU - Marossis, C.

AU - Gislason, T.

AU - Gislason, D.

AU - Bugiani, M.

AU - Bucca, C.

AU - Romano, C.

AU - Marinoni, A.

AU - Cerveri, T.

AU - Casali, L.

AU - Kremer, A.

AU - Crane, J.

AU - Lewis, S.

AU - Gulsvik, A.

AU - Omenaas, E.

AU - Muniozguren, N.

AU - Ramos González, J.

AU - Capelastegui, A.

AU - Castillo, J.

AU - Rodriguez Portal, J.

AU - Martinez-Moratalla, J.

AU - Almar, E.

AU - Maldonado Pérez, J.

AU - Pereira, A.

AU - Sánchez, J.

AU - Quiros, J.

AU - Huerta, I.

AU - Pavo, F.

AU - Rosenhall, L.

AU - Norrman, E.

AU - Lundbäck, B.

AU - Lindholm, N.

AU - Plaschke, P.

AU - Ackermann-Liebrich, U.

AU - Künzli, N.

AU - Perruchoud, A.

AU - Burr, M.

AU - Layzell, J.

AU - Hall, R.

AU - Harrison, B.

AU - Stark, J.

AU - Buist, S.

AU - Vollmer, W.

AU - Osborne, Molly

PY - 1997/11

Y1 - 1997/11

N2 - Attempts to compare bronchial responsiveness between populations have been hampered by between-study differences in the pharmacological agent of provocation, the method of administration and the summary statistic employed. The European Community Respiratory Health Survey used methacholine challenge delivered by Mefar dosimeter according to a standardized protocol used in 35 centres in 16 countries. Data were obtained from 13,161 men and women, aged 20-44 yrs at the start of the study. The dose of methacholine producing a 20% fall in forced expiratory volume in one second (FEV1) (PD20) and the regression coefficient of percentage decline in FEV1 with log dose, were calculated ('slope', after transformation), with and without calibration of nebulizers by weight and adjustment for nonresponsc bias. Standardization for baseline lung function and variation in smoking prevalence was applied to slope. Results were robust to whichever summary measure was used, and to the various adjustments. Responsiveness was low in Iceland and Switzerland, and in most centres in Sweden, Italy and Spain, and high in New Zealand, Australia, the USA, Britain, France, Denmark and Germany. Bronchial responsiveness varies considerably in Europe, and high levels are not confined to the English-speaking world.

AB - Attempts to compare bronchial responsiveness between populations have been hampered by between-study differences in the pharmacological agent of provocation, the method of administration and the summary statistic employed. The European Community Respiratory Health Survey used methacholine challenge delivered by Mefar dosimeter according to a standardized protocol used in 35 centres in 16 countries. Data were obtained from 13,161 men and women, aged 20-44 yrs at the start of the study. The dose of methacholine producing a 20% fall in forced expiratory volume in one second (FEV1) (PD20) and the regression coefficient of percentage decline in FEV1 with log dose, were calculated ('slope', after transformation), with and without calibration of nebulizers by weight and adjustment for nonresponsc bias. Standardization for baseline lung function and variation in smoking prevalence was applied to slope. Results were robust to whichever summary measure was used, and to the various adjustments. Responsiveness was low in Iceland and Switzerland, and in most centres in Sweden, Italy and Spain, and high in New Zealand, Australia, the USA, Britain, France, Denmark and Germany. Bronchial responsiveness varies considerably in Europe, and high levels are not confined to the English-speaking world.

KW - Bronchial provocation tests

KW - Epidemiology

KW - Methacholine

KW - Multi-centre study

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ER -

Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)

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Keywords

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