TY - JOUR
T1 - Vasoactive drugs in obstetrics
T2 - A review of data obtained by doppler and color doppler methods: Invited reviews
AU - Jouppila, Pentti
AU - Räsänen, Juha
AU - Alahuhta, Seppo
AU - Jouppila, Riitta
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - Objective: We did a literature review of the hemodynamic effects of different vasoactive agents, as assessed by Doppler and color Doppler methods. Methods: The review included reports dealing with the Doppler method assisted by basic ultrasound real-time, M-mode, and color Doppler techniques. Results and Conclusions: Maternal vasoactive drugs (labetalol, dihy-dralazine, pindolol, nifedipine), anesthesia, and maternal position do not hinder the uteroplacental and fetal circulation to the extent that clinical complications would ensue. However, if these factors are strong enough, an increased vascular resistance in the uterine arteries does appear without any immediate compromises in fetal hemodynamics. Some regulatory changes do occur, however, in the fetal cerebral and renal arteries and in fetal myocardial contractility. This signifies that some vasoactive drugs may compromise fetal hemodynamics, especially in fetuses with poor blood or oxygen supply before treatment. One good example of the fetal hemodynamic changes caused by maternal drug is the vasoconstriction of fetal ductus arteriosus during maternal intake of indo-methacin. and demonstrated by the Doppler technique. The circulatory safety of both routinely used vasoactive agents and new drugs can now be tested with the Doppler method more reliably than before. Increased understanding of uterine and fetal hemodynamic regulation in many different clinical conditions and their treatment schedules has benefited perinatal practice.
AB - Objective: We did a literature review of the hemodynamic effects of different vasoactive agents, as assessed by Doppler and color Doppler methods. Methods: The review included reports dealing with the Doppler method assisted by basic ultrasound real-time, M-mode, and color Doppler techniques. Results and Conclusions: Maternal vasoactive drugs (labetalol, dihy-dralazine, pindolol, nifedipine), anesthesia, and maternal position do not hinder the uteroplacental and fetal circulation to the extent that clinical complications would ensue. However, if these factors are strong enough, an increased vascular resistance in the uterine arteries does appear without any immediate compromises in fetal hemodynamics. Some regulatory changes do occur, however, in the fetal cerebral and renal arteries and in fetal myocardial contractility. This signifies that some vasoactive drugs may compromise fetal hemodynamics, especially in fetuses with poor blood or oxygen supply before treatment. One good example of the fetal hemodynamic changes caused by maternal drug is the vasoconstriction of fetal ductus arteriosus during maternal intake of indo-methacin. and demonstrated by the Doppler technique. The circulatory safety of both routinely used vasoactive agents and new drugs can now be tested with the Doppler method more reliably than before. Increased understanding of uterine and fetal hemodynamic regulation in many different clinical conditions and their treatment schedules has benefited perinatal practice.
KW - Color Doppler
KW - Doppler
KW - Drugs
KW - Pregnancy
KW - Prenatal
KW - Ultrasonography
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U2 - 10.3109/10641959509015673
DO - 10.3109/10641959509015673
M3 - Review article
AN - SCOPUS:0028892906
SN - 1064-1955
VL - 14
SP - 261
EP - 275
JO - Hypertension in Pregnancy
JF - Hypertension in Pregnancy
IS - 3
ER -