TY - JOUR
T1 - Visual Exploration While Walking With and Without Visual Cues in Parkinson’s Disease
T2 - Freezer Versus Non-Freezer
AU - Graham, Lisa
AU - Armitage, Jordan
AU - Vitorio, Rodrigo
AU - Das, Julia
AU - Barry, Gill
AU - Godfrey, Alan
AU - McDonald, Claire
AU - Walker, Richard
AU - Mancini, Martina
AU - Morris, Rosie
AU - Stuart, Samuel
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023/10
Y1 - 2023/10
N2 - Background: Visual cues can improve gait in Parkinson’s disease (PD), including those experiencing freezing of gait (FOG). However, responses are variable and underpinning mechanisms remain unclear. Visuo-cognitive processing (measured through visual exploration) has been implicated in cue response, but this has not been comprehensively examined. Objective: To examine visual exploration and gait with and without visual cues in PD who do and do not self-report FOG, and healthy controls (HC). Methods: 17 HC, 21 PD without FOG, and 22 PD with FOG walked with and without visual cues, under single and dual-task conditions. Visual exploration (ie, saccade frequency, duration, peak velocity, amplitude, and fixation duration) was measured via mobile eye-tracking and gait (ie, gait speed, stride length, foot strike angle, stride time, and stride time variability) with inertial sensors. Results: PD had impaired gait compared to HC, and dual-tasking made gait variables worse across groups (all P <.01). Visual cues improved stride length, foot strike angle, and stride time in all groups (P <.01). Visual cueing also increased saccade frequency, but reduced saccade peak velocity and amplitude in all groups (P <.01). Gait improvement related to changes in visual exploration with visual cues in PD but not HC, with relationships dependent on group (FOG vs non-FOG) and task (single vs dual). Conclusion: Visual cues improved visual exploration and gait outcomes in HC and PD, with similar responses in freezers and non-freezers. Freezer and non-freezer specific associations between cue-related changes in visual exploration and gait indicate different underlying visuo-cognitive processing within these subgroups for cue response.
AB - Background: Visual cues can improve gait in Parkinson’s disease (PD), including those experiencing freezing of gait (FOG). However, responses are variable and underpinning mechanisms remain unclear. Visuo-cognitive processing (measured through visual exploration) has been implicated in cue response, but this has not been comprehensively examined. Objective: To examine visual exploration and gait with and without visual cues in PD who do and do not self-report FOG, and healthy controls (HC). Methods: 17 HC, 21 PD without FOG, and 22 PD with FOG walked with and without visual cues, under single and dual-task conditions. Visual exploration (ie, saccade frequency, duration, peak velocity, amplitude, and fixation duration) was measured via mobile eye-tracking and gait (ie, gait speed, stride length, foot strike angle, stride time, and stride time variability) with inertial sensors. Results: PD had impaired gait compared to HC, and dual-tasking made gait variables worse across groups (all P <.01). Visual cues improved stride length, foot strike angle, and stride time in all groups (P <.01). Visual cueing also increased saccade frequency, but reduced saccade peak velocity and amplitude in all groups (P <.01). Gait improvement related to changes in visual exploration with visual cues in PD but not HC, with relationships dependent on group (FOG vs non-FOG) and task (single vs dual). Conclusion: Visual cues improved visual exploration and gait outcomes in HC and PD, with similar responses in freezers and non-freezers. Freezer and non-freezer specific associations between cue-related changes in visual exploration and gait indicate different underlying visuo-cognitive processing within these subgroups for cue response.
KW - Parkinson’s disease
KW - eye-tracking
KW - fixations
KW - freezing of gait
KW - saccades
KW - visual cues
KW - visual exploration
KW - walking
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U2 - 10.1177/15459683231201149
DO - 10.1177/15459683231201149
M3 - Article
C2 - 37772512
AN - SCOPUS:85173551718
SN - 1545-9683
VL - 37
SP - 734
EP - 743
JO - Neurorehabilitation and Neural Repair
JF - Neurorehabilitation and Neural Repair
IS - 10
ER -