Vitreo-retinal traction and anastrozole use

Alvin Eisner, Emily J. Thielman, Julie Falardeau, John T. Vetto

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Purpose: This study tested a prediction stemming from the hypothesis that anastrozole users experience heightened vitreo-retinal traction. This hypothesis was based on the knowledge that menopause increases the risk of intraocular tractional events such as posterior vitreous detachments (PVDs). Methods: Retinal thickness was measured for 3 groups of amenorrheic women: (1) anastrozole users and (2) tamoxifen users undergoing adjuvant therapy for early-stage breast cancer, and (3) control subjects not using hormonal medication. Foveal shape indices were derived for subjects without PVDs. Results: For anastrozole users, the distance to the temporal side of the fovea became less than the distance to the nasal side at a sufficient height above the foveal base. This effect did not exist for control subjects; the between-group difference was appreciable. Results concerning tamoxifen users were inconclusive. Conclusions: The foveas of women using anastrozole appear to be subjected to more tractional force than are the foveas of women not using any hormonal medication.

Original languageEnglish (US)
Pages (from-to)9-16
Number of pages8
JournalBreast Cancer Research and Treatment
Issue number1
StatePublished - Sep 2009


  • Aromatase inhibitor
  • Estrogen
  • Eye
  • Optical coherence tomography
  • Retina
  • Vitreous

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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