Waking and sleeping in the rat made obese through a highfat hypercaloric diet

Marco Luppi; Matteo Cerri; Davide Martelli; Domenico Tupone; Flavia Del Vecchio; Alessia Di Cristoforo; Emanuele Perez; Giovanni Zamboni; Roberto Amici

doi:10.1201/b17253

Waking and sleeping in the rat made obese through a highfat hypercaloric diet

Marco Luppi, Matteo Cerri, Davide Martelli, Domenico Tupone, Flavia Del Vecchio, Alessia Di Cristoforo, Emanuele Perez, Giovanni Zamboni, Roberto Amici

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A possible link between insufficient sleep and metabolism dysregulation has been suggested by studies showing that a prolonged sleep curtailment may act as a key co-factor for the development of obesity and/or metabolic syndrome [1]. Sleep restriction protocols have been shown to reduce glucose tolerance and insulin sensitivity and to reduce the leptin/ghrelin ratio, possibly leading subjects to eat more than needed [1]. These data have been partly confirmed by the results of a recent study, showing that sleep restriction induced an increase in energy expenditure which was overcompensated by an increase in energy intake leading to weight gain, in spite of a concomitant increase in the leptin/ghrelin ratio [2].

Original language	English (US)
Title of host publication	Sleep, Circadian Rhythms, and Metabolism
Subtitle of host publication	The Rhythm of Life
Publisher	Apple Academic Press
Pages	299-318
Number of pages	20
ISBN (Electronic)	9781482262650
ISBN (Print)	9781771880626
DOIs	https://doi.org/10.1201/b17253
State	Published - Jan 1 2014
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1201/b17253

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abstract = "A possible link between insufficient sleep and metabolism dysregulation has been suggested by studies showing that a prolonged sleep curtailment may act as a key co-factor for the development of obesity and/or metabolic syndrome [1]. Sleep restriction protocols have been shown to reduce glucose tolerance and insulin sensitivity and to reduce the leptin/ghrelin ratio, possibly leading subjects to eat more than needed [1]. These data have been partly confirmed by the results of a recent study, showing that sleep restriction induced an increase in energy expenditure which was overcompensated by an increase in energy intake leading to weight gain, in spite of a concomitant increase in the leptin/ghrelin ratio [2].",

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AU - Luppi, Marco

AU - Cerri, Matteo

AU - Martelli, Davide

AU - Tupone, Domenico

AU - Del Vecchio, Flavia

AU - Di Cristoforo, Alessia

AU - Perez, Emanuele

AU - Zamboni, Giovanni

AU - Amici, Roberto

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AB - A possible link between insufficient sleep and metabolism dysregulation has been suggested by studies showing that a prolonged sleep curtailment may act as a key co-factor for the development of obesity and/or metabolic syndrome [1]. Sleep restriction protocols have been shown to reduce glucose tolerance and insulin sensitivity and to reduce the leptin/ghrelin ratio, possibly leading subjects to eat more than needed [1]. These data have been partly confirmed by the results of a recent study, showing that sleep restriction induced an increase in energy expenditure which was overcompensated by an increase in energy intake leading to weight gain, in spite of a concomitant increase in the leptin/ghrelin ratio [2].

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Waking and sleeping in the rat made obese through a highfat hypercaloric diet

Abstract

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