Waking and sleeping in the rat made obese through a highfat hypercaloric diet

Marco Luppi, Matteo Cerri, Davide Martelli, Domenico Tupone, Flavia Del Vecchio, Alessia Di Cristoforo, Emanuele Perez, Giovanni Zamboni, Roberto Amici

Research output: Chapter in Book/Report/Conference proceedingChapter


A possible link between insufficient sleep and metabolism dysregulation has been suggested by studies showing that a prolonged sleep curtailment may act as a key co-factor for the development of obesity and/or metabolic syndrome [1]. Sleep restriction protocols have been shown to reduce glucose tolerance and insulin sensitivity and to reduce the leptin/ghrelin ratio, possibly leading subjects to eat more than needed [1]. These data have been partly confirmed by the results of a recent study, showing that sleep restriction induced an increase in energy expenditure which was overcompensated by an increase in energy intake leading to weight gain, in spite of a concomitant increase in the leptin/ghrelin ratio [2].

Original languageEnglish (US)
Title of host publicationSleep, Circadian Rhythms, and Metabolism
Subtitle of host publicationThe Rhythm of Life
PublisherApple Academic Press
Number of pages20
ISBN (Electronic)9781482262650
ISBN (Print)9781771880626
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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