Wavefront-guided versus wavefront-optimized photorefractive keratectomy: Clinical outcomes and patient satisfaction

Rose K. Sia, Denise S. Ryan, Richard D. Stutzman, Joseph F. Pasternak, Jennifer B. Eaddy, Lorie A. Logan, Mark F. Torres, Kraig S. Bower

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Purpose To compare visual outcomes following Visx Star S4 Customvue wavefront-guided and Allegretto Wave Eye-Q 400 Hz wavefront-optimized photorefractive keratectomy (PRK). Setting Warfighter Refractive Eye Surgery Program and Research Center, Fort Belvoir, Virginia, and Walter Reed National Military Medical Center, Bethesda, Maryland, USA. Design Prospective randomized clinical trial. Methods Active-duty United States military soldiers were randomized to have wavefront-guided (Visx Star S4 Customvue) or wavefront-optimized PRK. Participants were followed up to 12 months postoperatively. Primary outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and manifest spherical equivalent (SE). Secondary outcome measures included refractive astigmatism, higher-order aberrations (HOAs), contrast sensitivity, subjective visual complaints, and patient satisfaction. Results The study evaluated 108 soldiers (mean age 30.3 years ± 6.3 [SD]; mean manifest SE -3.51 ± 1.63 D). At 12 months postoperatively, achieved UDVA, CDVA, manifest SE, and refractive astigmatism were comparable between wavefront-guided and wavefront-optimized groups (P >.213). Spherical aberration and total HOAs significantly increased from baseline in both groups (P <.006). The change in coma, trefoil, spherical aberration, and total HOAs (P >.254) were comparable between groups. There were fewer losses of photopic low-contrast visual acuity (LCVA) at 5% contrast after wavefront-guided compared to wavefront-optimized treatment (P =.003). There was no significant difference between treatment groups in visual symptoms, overall vision expectation, and satisfaction (P >.075). Conclusion Wavefront-guided treatment offered a small advantage in photopic LCVA. Refractive outcomes, HOAs, self-reported visual difficulties, overall vision expectation, and satisfaction were otherwise comparable between wavefront-guided and wavefront-optimized treatments. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.

Original languageEnglish (US)
Pages (from-to)2152-2164
Number of pages13
JournalJournal of cataract and refractive surgery
Issue number10
StatePublished - Oct 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology
  • Sensory Systems


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