What Does the Frontopolar Cortex Contribute to Goal-Directed Cognition and Action?

Jeremy Hogeveen, Maria Medalla, Matthew Ainsworth, Juan M. Galeazzi, Colleen A. Hanlon, Farshad Alizadeh Mansouri, Vincent D. Costa

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Understanding the unique functions of different subregions of primate prefrontal cortex has been a longstanding goal in cognitive neuroscience. Yet, the anatomy and function of one of its largest subregions (the frontopolar cortex) remain enigmatic and underspecified. Our Society for Neuroscience minisymposium Primate Frontopolar Cortex: From Circuits to Complex Behaviors will comprise a range of new anatomic and functional approaches that have helped to clarify the basic circuit anatomy of the frontal pole, its functional involvement during performance of cognitively demanding behavioral paradigms in monkeys and humans, and its clinical potential as a target for noninvasive brain stimulation in patients with brain disorders. This review consolidates knowledge about the anatomy and connectivity of frontopolar cortex and provides an integrative summary of its function in primates.

Original languageEnglish (US)
Pages (from-to)8508-8513
Number of pages6
JournalJournal of Neuroscience
Issue number45
StatePublished - Nov 9 2022


  • Area 10
  • cognitive control
  • decision-making
  • explore/exploit
  • frontal pole
  • nonhuman primates

ASJC Scopus subject areas

  • Neuroscience(all)


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