TY - JOUR
T1 - Where is the locus in opioid withdrawal?
AU - Christie, MacDonald J.
AU - Williams, John T.
AU - Osborne, Peregrine B.
AU - Bellchambers, Clare E.
N1 - Funding Information:
Admowledpemeets I would lhket o thank SusanJ ones,David Armstrong.B rianP emno and Paul Kelly for helpful commentsa nd critical readingo f the manuscripta. nd to thank BrianP errinoa nd Rlchatd Twnf orp rovidmmge with manuswpts prior to publication The author’s researchw as supported by the NIH intramural programme M. J. Christie, Associate Professor. Department of Pharmacology, The University of Sydney, NSW 2006. Australia, J. T. Williams, Senior Scientist. Vellum Institute. Oregon Health Sciences University, Portland. OR 97201, USA, P. B. Osborne, Postdoctoral Research MOW. Department of Physiology and Pharmacology, University of Oueensland. Brisbane. OLD 4072. Australia, and C. E. Bellchambers, Research Student. Department of Pharmacology. The University of Sydney. NSW 2006. Australia.
PY - 1997/4
Y1 - 1997/4
N2 - Identification of neuroadaptations in specific brain regions that generate withdrawal is crucial for understanding and perhaps treating opioid dependence. It has been widely proposed that the locus coeruleus (LC) is the nucleus that plays the primary causal role in the expression of the opioid withdrawal syndrome. MacDonald Christie, John Williams, Peregrine Osborne and Clare Bellchambers believe that this view and the interpretation of the literature on which it is based are at best controversial. Here, they suggest an alternative view in which regions close to the LC such as the periaqueductal grey, as well as other brain structures which are independent of the LC noradrenergic system, play a more important role in the expression of the opioid withdrawal syndrome.
AB - Identification of neuroadaptations in specific brain regions that generate withdrawal is crucial for understanding and perhaps treating opioid dependence. It has been widely proposed that the locus coeruleus (LC) is the nucleus that plays the primary causal role in the expression of the opioid withdrawal syndrome. MacDonald Christie, John Williams, Peregrine Osborne and Clare Bellchambers believe that this view and the interpretation of the literature on which it is based are at best controversial. Here, they suggest an alternative view in which regions close to the LC such as the periaqueductal grey, as well as other brain structures which are independent of the LC noradrenergic system, play a more important role in the expression of the opioid withdrawal syndrome.
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U2 - 10.1016/S0165-6147(97)01045-6
DO - 10.1016/S0165-6147(97)01045-6
M3 - Review article
C2 - 9149542
AN - SCOPUS:0030887289
SN - 0165-6147
VL - 18
SP - 134
EP - 140
JO - Trends in pharmacological sciences
JF - Trends in pharmacological sciences
IS - 4
ER -