Brenden-Colson Center for Pancreatic Health

Research output

Research output per year 2003 2018 2019 2020 2021 2022 2023 2024

• 54 Article
• 2 Chapter
• 2 Review article

Research output per year

Research output per year

Search results

• 2024

  Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

  Alshaikh, A., Grygoryev, D., Keith, D., Sheppard, B., Sears, R. C., Kim, J. & Soufi, A., Feb 2024, In: Journal of Visualized Experiments. 2024, 204, e65811.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells 100%
  • Biological Marker 63%
  • Adenocarcinoma 55%
  • Induced Pluripotent Stem Cells 46%
  • Marker 31%

• Sendai virus is robust and consistent in delivering genes into human pancreatic cancer cells

  Grygoryev, D., Ekstrom, T., Manalo, E., Link, J., Alshaikh, A., Keith, D., Allen-Petersen, B. L., Sheppard, B., Morgan, T., Soufi, A., Sears, R. C. & Kim, J., Mar 15 2024, In: Heliyon. 10, 5, e27221.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sendai virus 100%
  • Pancreatic Neoplasms 70%
  • Adenocarcinoma 58%
  • Genes 29%
  • vesicular stomatitis virus G protein 15%
• 2023

  Accessible high-throughput single-cell whole-genome sequencing with paired chromatin accessibility

  Queitsch, K., Moore, T. W., O'Connell, B. L., Nichols, R. V., Muschler, J. L., Keith, D., Lopez, C., Sears, R. C., Mills, G. B., Yardımcı, G. G. & Adey, A. C., Nov 20 2023, In: Cell Reports Methods. 3, 11, 100625.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Genome Sequencing 100%
  • Genomics 89%
  • Chromatin 75%
  • Throughput 59%
  • Reagents 29%

• An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences

  Gurun, B., Horton, W., Murugan, D., Zhu, B., Leyshock, P., Kumar, S., Byrne, K. T., Vonderheide, R. H., Margolin, A. A., Mori, M., Spellman, P. T., Coussens, L. M. & Speed, T. P., Dec 2023, In: BMC Genomics. 24, 1, 349.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T-Lymphocytes 100%
  • T-Cell Antigen Receptor 82%
  • High-Throughput Nucleotide Sequencing 77%
  • Costs and Cost Analysis 50%
  • DNA 45%

• Deletion of the mRNA stability factor ELAVL1 (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity

  McCarthy, G. A., Di Niro, R., Finan, J. M., Jain, A., Guo, Y., Wyatt, C. R., Guimaraes, A. R., Waugh, T. A., Keith, D., Morgan, T. K., Sears, R. C. & Brody, J. R., Jun 1 2023, In: NAR Cancer. 5, 2, zcad016.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Stability 100%
  • Tumor Microenvironment 94%
  • Pancreatic Neoplasms 86%
  • Platelet-Derived Growth Factor 78%
  • Adenocarcinoma 71%
  3 Scopus citations

• T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control

  Steele, M. M., Jaiswal, A., Delclaux, I., Dryg, I. D., Murugan, D., Femel, J., Son, S., du Bois, H., Hill, C., Leachman, S. A., Chang, Y. H., Coussens, L. M., Anandasabapathy, N. & Lund, A. W., Apr 2023, In: Nature Immunology.

  Research output: Contribution to journal › Article › peer-review

  • Lymphatic Vessels 100%
  • Antigens 52%
  • T-Lymphocytes 51%
  • Neoplasms 26%
  • Immunotherapy 16%
  23 Scopus citations
• 2022

  Heterodimeric RGD-NGR PET Tracer for the Early Detection of Pancreatic Cancer

  Sun, L., Gai, Y., Li, Z., Li, H., Li, J., Muschler, J., Kang, R., Tang, D. & Zeng, D., Aug 2022, In: Molecular Imaging and Biology. 24, 4, p. 580-589 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Early Detection of Cancer 100%
  • Pancreatic Neoplasms 99%
  • Adenocarcinoma 55%
  • Fluorodeoxyglucose F18 36%
  • Staining and Labeling 30%
  8 Scopus citations

• Lipopolysaccharide-induced hypothalamic inflammation in cancer cachexia-anorexia is amplified by tumour-derived prostaglandin E2

  Li, X., Holtrop, T., Jansen, F. A. C., Olson, B., Levasseur, P., Zhu, X., Poland, M., Schalwijk, W., Witkamp, R. F., Marks, D. L. & van Norren, K., Dec 2022, In: Journal of Cachexia, Sarcopenia and Muscle. 13, 6, p. 3014-3027 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cachexia 100%
  • Anorexia 88%
  • Dinoprostone 79%
  • Lipopolysaccharides 69%
  • Inflammation 48%

• Neoadjuvant Therapy Is Associated with Improved Chemotherapy Delivery and Overall Survival Compared to Upfront Resection in Pancreatic Cancer without Increasing Perioperative Complications

  Deig, C. R., Sutton, T. L., Beneville, B., Trone, K., Stratton, A., Gunesch, A. N., Liu, A. I., Alrohaibani, A., Mohebnasab, M., Bassale, S., Grossblatt-Wait, A., Keith, D., Attia, F., Gilbert, E. W., Lopez, C. D., Kardosh, A., Chen, E. Y., Bensch, K. G., Nabavizadeh, N., Thomas, C. R., & 3 othersMayo, S. C., Sheppard, B. C. & Grossberg, A., Feb 1 2022, In: Cancers. 14, 3, 609.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoadjuvant Therapy 100%
  • Pancreatic Neoplasms 82%
  • Drug Therapy 50%
  • Survival 48%
  • Chemoradiotherapy 18%
  3 Scopus citations

• Targeted delivery of harmine to xenografted human pancreatic islets promotes robust cell proliferation

  Mishra, S. & Streeter, P. R., Dec 2022, In: Scientific Reports. 12, 1, 19127.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Harmine 100%
  • Islets of Langerhans 60%
  • Cell Proliferation 39%
  • Endocrine Cells 30%
  • Pharmaceutical Preparations 14%
  1 Scopus citations
• 2021

  Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment

  Olson, B., Zhu, X., Norgard, M. A., Diba, P., Levasseur, P. R., Buenafe, A. C., Huisman, C., Burfeind, K. G., Michaelis, K. A., Kong, G., Braun, T. & Marks, D. L., Oct 2021, In: Brain, Behavior, and Immunity. 97, p. 102-118 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipocalin-2 100%
  • Cognitive Dysfunction 61%
  • Central Nervous System 14%
  • Neurons 12%
  • Cachexia 12%
  24 Scopus citations

• Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer

  Vayrynen, S. A., Zhang, J., Yuan, C., Vayrynen, J. P., Costa, A. D., Williams, H., Morales-Oyarvide, V., Lau, M. C., Rubinson, D. A., Dunne, R. F., Kozak, M. M., Wang, W., Agostini-Vulaj, D., Drage, M. G., Brais, L., Reilly, E., Rahma, O., Clancy, T., Wang, J., Linehan, D. C., & 9 othersAguirre, A. J., Fuchs, C. S., Coussens, L. M., Chang, D. T., Koong, A. C., Hezel, A. F., Ogino, S., Nowak, J. A. & Wolpin, B. M., Feb 15 2021, In: Clinical Cancer Research. 27, 4, p. 1069-1081 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloid Cells 100%
  • Pancreatic Neoplasms 92%
  • Adenocarcinoma 54%
  • Macrophages 29%
  • Tumor Microenvironment 29%
  74 Scopus citations

• Leukocyte heterogeneity in pancreatic ductal adenocarcinoma: Phenotypic and spatial features associated with clinical outcome

  Liudahl, S. M., Betts, C. B., Sivagnanam, S., Morales-Oyarvide, V., Silva, A. D., Yuan, C., Hwang, S., Grossblatt-Wait, A., Leis, K. R., Larson, W., Lavoie, M. B., Robinson, P., Costa, A. D., Väyrynen, S. A., Clancy, T. E., Rubinson, D. A., Link, J., Keith, D., Horton, W., Tempero, M. A., & 10 othersVonderheide, R. H., Jaffee, E. M., Sheppard, B., Goecks, J., Sears, R. C., Park, B. S., Mori, M., Nowak, J. A., Wolpin, B. M. & Coussens, L. M., Aug 2021, In: Cancer discovery. 11, 8, p. 2014-2031 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leukocytes 100%
  • Adenocarcinoma 98%
  • Atlases 58%
  • Neoadjuvant Therapy 20%
  • Ecosystem 19%
  72 Scopus citations

• Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia

  Olson, B., Zhu, X., Norgard, M. A., Levasseur, P. R., Butler, J. T., Buenafe, A., Burfeind, K. G., Michaelis, K. A., Pelz, K. R., Mendez, H., Edwards, J., Krasnow, S. M., Grossberg, A. J. & Marks, D. L., Dec 1 2021, In: Nature communications. 12, 1, 2057.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Melanocortin 100%
  • Lipocalin-2 85%
  • Cachexia 78%
  • Appetite 66%
  • Fat 63%
  50 Scopus citations

• Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia

  Olson, B., Norgard, M. A., Levasseur, P. R., Zhu, X. & Marks, D. L., Oct 2021, In: Journal of Cachexia, Sarcopenia and Muscle. 12, 5, p. 1312-1332 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cachexia 100%
  • Head and Neck Neoplasms 81%
  • Neoplasms 18%
  • Fats 10%
  • Papillomaviridae 5%
  8 Scopus citations

• Tumor-infiltrating leukocyte phenotypes distinguish outcomes in related patients with pancreatic adenocarcinoma

  Link, J. M., Liudahl, S. M., Betts, C. B., Sivagnanam, S., Leis, K. R., McDonnell, M., Pelz, C. R., Johnson, B., Hamman, K. J., Keith, D., Sampson, J. E., Morgan, T. K., Lopez, C. D., Coussens, L. M. & Sears, R. C., 2021, In: JCO Precision Oncology. 5, p. 344-356 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Scopus citations
• 2020

  Association of Sarcopenia with Oncologic Outcomes of Primary Surgery or Definitive Radiotherapy among Patients with Localized Oropharyngeal Squamous Cell Carcinoma

  Clayburgh, D., Olson, B., Edwards, J., Stone, L., Jiang, A., Zhu, X., Holland, J., Li, R., Andersen, P., Krasnow, S. & Marks, D. L., Aug 2020, In: JAMA Otolaryngology - Head and Neck Surgery. 146, 8, p. 714-722 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sarcopenia 100%
  • Squamous Cell Carcinoma 67%
  • Radiotherapy 55%
  • Survival 44%
  • Skeletal Muscle 13%
  21 Scopus citations

• Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

  Burfeind, K. G., Zhu, X., Norgard, M. A., Levasseur, P. R., Huisman, C., Buenafe, A. C., Olson, B., Michaelis, K. A., Torres, E. R. S., Jeng, S., McWeeney, S., Raber, J. & Marks, D. L., May 2020, In: eLife. 9, p. 1-27 27 p., e54095.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intracerebroventricular 100%
  • Cachexia 76%
  • Myeloid Cells 63%
  • Pancreatic Neoplasms 59%
  • Anorexia 50%
  37 Scopus citations

• Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- And chronic kidney disease-associated cachexia

  Zhu, X., Callahan, M. F., Gruber, K. A., Szumowski, M. & Marks, D. L., Sep 1 2020, In: Journal of Clinical Investigation. 130, 9, p. 4921-4934 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptor, Melanocortin, Type 4 100%
  • Cachexia 83%
  • Chronic Renal Insufficiency 62%
  • Melanocortins 41%
  • Anorexia 31%
  20 Scopus citations

• Microglia in the hypothalamus respond to tumor-derived factors and are protective against cachexia during pancreatic cancer

  Burfeind, K. G., Zhu, X., Norgard, M. A., Levasseur, P. R., Huisman, C., Michaelis, K. A., Olson, B. & Marks, D. L., Jul 1 2020, In: GLIA. 68, 7, p. 1479-1494 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cachexia 100%
  • Protective Factors 88%
  • Microglia 82%
  • Pancreatic Neoplasms 77%
  • Hypothalamus 75%
  17 Scopus citations

• Myeloid cells orchestrate systemic immunosuppression, impairing the efficacy of immunotherapy against HPV^þ cancers

  Galliverti, G., Wullschleger, S., Tichet, M., Murugan, D., Zangger, N., Horton, W., Korman, A. J., Coussens, L. M., Swartz, M. A. & Hanahan, D., 2020, In: Cancer Immunology Research. 8, 1, p. 131-145 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloid Cells 100%
  • Immunosuppression 88%
  • Immunotherapy 86%
  • T-Lymphocytes 40%
  • Vaccines 36%
  20 Scopus citations

• VISTA: VIsual Semantic Tissue Analysis for pancreatic disease quantification in murine cohorts

  Ternes, L., Huang, G., Lanciault, C., Thibault, G., Riggers, R., Gray, J. W., Muschler, J. & Chang, Y. H., Dec 2020, In: Scientific Reports. 10, 1, 20904.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Diseases 100%
  • Metaplasia 84%
  • Semantics 80%
  • Amylases 56%
  • Keratins 53%
  5 Scopus citations
• 2019

  3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy

  França, C. M., Riggers, R., Muschler, J. L., Widbiller, M., Lococo, P. M., Diogenes, A. & Bertassoni, L. E., Dec 1 2019, In: Scientific Reports. 9, 1, 10860.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acrylamide 100%
  • Dental Pulp 96%
  • Hydrogels 81%
  • Microscopy 63%
  • Lipids 50%
  28 Scopus citations

• Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma

  Hassan, R., Alley, E., Kindler, H., Antonia, S., Jahan, T., Honarmand, S., Nair, N., Whiting, C. C., Enstrom, A., Lemmens, E., Tsujikawa, T., Kumar, S., Choe, G., Thomas, A., McDougall, K., Murphy, A. L., Jaffee, E., Coussens, L. M. & Brockstedt, D. G., Oct 1 2019, In: Clinical Cancer Research. 25, 19, p. 5787-5798 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • mesothelin 100%
  • Malignant Mesothelioma 77%
  • Listeria monocytogenes 74%
  • Drug Therapy 37%
  • Neoplasms 20%
  70 Scopus citations

• Convergent neuronal projections from paraventricular nucleus, parabrachial nucleus, and brainstem onto gastrocnemius muscle, white and brown adipose tissue in male rats

  Doslikova, B., Tchir, D., McKinty, A., Zhu, X., Marks, D. L., Baracos, V. E. & Colmers, W. F., Dec 1 2019, In: Journal of Comparative Neurology. 527, 17, p. 2826-2842 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parabrachial Nucleus 100%
  • Brown Adipose Tissue 85%
  • White Adipose Tissue 84%
  • Paraventricular Hypothalamic Nucleus 81%
  • Brain Stem 62%
  12 Scopus citations

• MyD88 signalling is critical in the development of pancreatic cancer cachexia

  Zhu, X., Burfeind, K. G., Michaelis, K. A., Braun, T. P., Olson, B., Pelz, K. R., Morgan, T. K. & Marks, D. L., Apr 2019, In: Journal of Cachexia, Sarcopenia and Muscle. 10, 2, p. 378-390 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cachexia 100%
  • Pancreatic Neoplasms 77%
  • Inflammation 38%
  • Adenocarcinoma 25%
  • Wasting Syndrome 22%
  39 Scopus citations

• Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance

  Michaelis, K. A., Norgard, M. A., Levasseur, P. R., Olson, B., Burfeind, K. G., Buenafe, A. C., Zhu, X., Jeng, S., McWeeney, S. K. & Marks, D. L., Nov 2019, In: Brain, Behavior, and Immunity. 82, p. 338-353 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • resiquimod 100%
  • Toll-Like Receptor 7 91%
  • Immune Tolerance 74%
  • Microglia 26%
  • Lipopolysaccharides 15%
  24 Scopus citations
• 2018

  Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy

  Medler, T. R., Murugan, D., Horton, W., Kumar, S., Cotechini, T., Forsyth, A. M., Leyshock, P., Leitenberger, J. J., Kulesz-Martin, M., Margolin, A., Werb, Z. & Coussens, L. M., Oct 8 2018, In: Cancer Cell. 34, 4, p. 561-578.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Complement C5a 100%
  • Carcinogenesis 50%
  • Macrophages 45%
  • T-Lymphocytes 40%
  • Drug Therapy 38%
  115 Scopus citations

• Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

  Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., Cogdill, A. P., Zhao, L., Hudgens, C. W., Hutchinson, D. S., Manzo, T., Petaccia De Macedo, M., Cotechini, T., Kumar, T., Chen, W. S., Reddy, S. M., & 50 othersSzczepaniak Sloane, R., Galloway-Pena, J., Jiang, H., Chen, P. L., Shpall, E. J., Rezvani, K., Alousi, A. M., Chemaly, R. F., Shelburne, S., Vence, L. M., Okhuysen, P. C., Jensen, V. B., Swennes, A. G., McAllister, F., Marcelo Riquelme Sanchez, E., Zhang, Y., Le Chatelier, E., Zitvogel, L., Pons, N., Austin-Breneman, J. L., Haydu, L. E., Burton, E. M., Gardner, J. M., Sirmans, E., Hu, J., Lazar, A. J., Tsujikawa, T., Diab, A., Tawbi, H., Glitza, I. C., Hwu, W. J., Patel, S. P., Woodman, S. E., Amaria, R. N., Davies, M. A., Gershenwald, J. E., Hwu, P., Lee, J. E., Zhang, J., Coussens, L. M., Cooper, Z. A., Futreal, P. A., Daniel, C. R., Ajami, N. J., Petrosino, J. F., Tetzlaff, M. T., Sharma, P., Allison, J. P., Jenq, R. R. & Wargo, J. A., Jan 5 2018, In: Science. 359, 6371, p. 97-103 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gastrointestinal Microbiome 100%
  • Immunotherapy 89%
  • Melanoma 84%
  • Fecal Microbiota Transplantation 18%
  • Programmed Cell Death 1 Receptor 18%
  2896 Scopus citations

• Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer

  Pennock, N. D., Martinson, H. A., Guo, Q., Betts, C. B., Jindal, S., Tsujikawa, T., Coussens, L. M., Borges, V. F. & Schedin, P., Oct 1 2018, In: Journal for immunotherapy of cancer. 6, 1, 98.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ibuprofen 100%
  • Postpartum Period 81%
  • Macrophages 59%
  • Breast Neoplasms 54%
  • T-Lymphocytes 52%
  46 Scopus citations

• Increasing lean muscle mass in mice via nanoparticle-mediated hepatic delivery of follistatin mRNA

  Schumann, C., Nguyen, D. X., Norgard, M., Bortnyak, Y., Korzun, T., Chan, S., Lorenz, A. S., Moses, A. S., Albarqi, H. A., Wong, L., Michaelis, K., Zhu, X., Alani, A. W. G., Taratula, O. R., Krasnow, S., Marks, D. L. & Taratula, O., 2018, In: Theranostics. 8, 19, p. 5276-5288 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Follistatin 100%
  • Nanoparticles 61%
  • Muscles 41%
  • Messenger RNA 39%
  • Myostatin 39%
  30 Scopus citations

• TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia

  Burfeind, K. G., Zhu, X., Levasseur, P. R., Michaelis, K. A., Norgard, M. A. & Marks, D. L., Oct 2018, In: Brain, Behavior, and Immunity. 73, p. 364-374 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Illness Behavior 100%
  • Cachexia 89%
  • Lipopolysaccharides 62%
  • Hypothalamus 40%
  • Pancreatic Neoplasms 27%
  31 Scopus citations
• 2017

  Establishment and characterization of a novel murine model of pancreatic cancer cachexia

  Michaelis, K. A., Zhu, X., Burfeind, K. G., Krasnow, S. M., Levasseur, P. R., Morgan, T. K. & Marks, D. L., Oct 2017, In: Journal of Cachexia, Sarcopenia and Muscle. 8, 5, p. 824-838 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cachexia 100%
  • Pancreatic Neoplasms 77%
  • Adenocarcinoma 45%
  • Uncoupling Protein 1 33%
  • Wasting Syndrome 16%
  86 Scopus citations

• Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging

  Wang, L., Barth, C. W., Sibrian-Vazquez, M., Escobedo, J. O., Lowry, M., Muschler, J., Li, H., Gibbs, S. L. & Strongin, R. M., Jan 31 2017, In: ACS Omega. 2, 1, p. 154-163 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Infrared radiation 100%
  • Imaging techniques 88%
  • Fluorescent Probe 71%
  • Probe 70%
  • Molecular Probe 45%
  23 Scopus citations
• 2016

  A distinct brain pathway links viral RNA exposure to sickness behavior

  Zhu, X., Levasseur, P. R., Michaelis, K. A., Burfeind, K. G. & Marks, D. L., Jul 20 2016, In: Scientific Reports. 6, 29885.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Illness Behavior 100%
  • Viral RNA 79%
  • Brain 35%
  • Infections 34%
  • Poly I-C 30%
  28 Scopus citations

• Dexamethasone chemotherapy does not disrupt orexin signaling

  Kram, D. E., Krasnow, S. M., Levasseur, P. R., Zhu, X., Stork, L. C. & Marks, D. L., Dec 2016, In: PloS one. 11, 12, e0168731.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orexins 100%
  • Dexamethasone 70%
  • Drug Therapy 45%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 30%
  • Steroids 28%
  5 Scopus citations
• 2015

  Maternal high-fat diet and obesity compromise fetal hematopoiesis

  Kamimae-Lanning, A. N., Krasnow, S. M., Goloviznina, N. A., Zhu, X., Roth-Carter, Q. R., Levasseur, P. R., Jeng, S., McWeeney, S. K., Kurre, P. & Marks, D. L., Jan 1 2015, In: Molecular Metabolism. 4, 1, p. 25-38 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hematopoiesis 100%
  • High Fat Diet 92%
  • Hematopoietic Stem Cells 90%
  • Obesity 64%
  • Mothers 58%
  44 Scopus citations
• 2014

  Endocytic trafficking of laminin is controlled by dystroglycan and is disrupted in cancers

  Leonoudakis, D., Huang, G., Akhavan, A., Fata, J. E., Singh, M., Gray, J. W. & Muschler, J. L., 2014, In: Journal of Cell Science. 127, 22, p. 4894-4903 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dystroglycans 100%
  • Laminin 74%
  • Basement Membrane 22%
  • Laminin Receptors 22%
  • Neoplasms 22%
  22 Scopus citations

• Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke

  Zuloaga, K. L., Krasnow, S. M., Zhu, X., Zhang, W., Jouihan, S. A., Shangraw, R. E., Alkayed, N. J. & Marks, D. L., May 13 2014, In: PloS one. 9, 5, e97529.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epoxide Hydrolases 100%
  • Psychological Inhibition 58%
  • Stroke 49%
  • 4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid 29%
  • Middle Cerebral Artery Infarction 23%
  24 Scopus citations

• Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle

  Braun, T. P., Szumowski, M., Levasseur, P. R., Grossberg, A. J., Zhu, X., Agarwal, A. & Marks, D. L., Sep 25 2014, In: PloS one. 9, 9, e106489.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • muscular atrophy 100%
  • Glucocorticoid 88%
  • Muscular Atrophy 79%
  • glucocorticoids 73%
  • drug therapy 68%
  62 Scopus citations
• 2013

  Cancer- and endotoxin-induced cachexia require intact glucocorticoid signaling in skeletal muscle

  Braun, T. P., Grossberg, A. J., Krasnow, S. M., Levasseur, P. R., Szumowski, M., Zhu, X. X., Maxson, J. E., Knoll, J. G., Barnes, A. P. & Marks, D. L., Sep 2013, In: FASEB Journal. 27, 9, p. 3572-3582 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucocorticoid 100%
  • Cachexia 95%
  • Myeloid Differentiation Factor 88 91%
  • Endotoxins 77%
  • Glucocorticoids 70%
  83 Scopus citations
• 2012

  Hypothalamic signaling in anorexia induced by indispensable amino acid deficiency

  Zhu, X., Krasnow, S. M., Roth-Carter, Q. R., Levasseur, P. R., Braun, T. P., Grossberg, A. J. & Marks, D. L., Dec 15 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 303, 12, p. E1446-E1458

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Anorexia 100%
  • Melanocortins 66%
  • Amino Acids 64%
  • Piriform Cortex 62%
  • Uncoupling Protein 1 44%
  18 Scopus citations

• Loss of cell-surface laminin anchoring promotes tumor growth and is associated with poor clinical outcomes

  Akhavan, A., Griffith, O. L., Soroceanu, L., Leonoudakis, D., Luciani-Torres, M. G., Daemen, A., Gray, J. W. & Muschler, J. L., May 15 2012, In: Cancer Research. 72, 10, p. 2578-2588 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Laminin 100%
  • Growth 46%
  • Neoplasms 29%
  • Brain Neoplasms 17%
  • Disease Progression 14%
  44 Scopus citations

• Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice

  O'Rourke, R. W., White, A. E., Metcalf, M. D., Winters, B. R., Diggs, B. S., Zhu, X. & Marks, D. L., Aug 2012, In: Metabolism: Clinical and Experimental. 61, 8, p. 1152-1161 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Knockout Mice 100%
  • Insulin Resistance 89%
  • Inflammation 64%
  • Obesity 63%
  • Macrophages 50%
  126 Scopus citations
• 2011

  Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis

  Braun, T. P., Zhu, X., Szumowski, M., Scott, G. D., Grossberg, A. J., Levasseur, P. R., Graham, K., Khan, S., Damaraju, S., Colmers, W. F., Baracos, V. E. & Marks, D. L., Nov 21 2011, In: Journal of Experimental Medicine. 208, 12, p. 2449-2463 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Muscular Atrophy 100%
  • Central Nervous System 64%
  • Atrophy 56%
  • Muscles 52%
  • Inflammation 51%
  155 Scopus citations

• Inflammation-induced lethargy is mediated by suppression of orexin neuron activity

  Grossberg, A. J., Zhu, X., Leinninger, G. M., Levasseur, P. R., Braun, T. P., Myers, M. G. & Marks, D. L., Aug 3 2011, In: Journal of Neuroscience. 31, 31, p. 11376-11386 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orexins 100%
  • Lethargy 94%
  • Neurons 47%
  • Inflammation 45%
  • Locomotion 37%
  105 Scopus citations
• 2010

  Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130

  Grossberg, A. J., Scarlett, J. M., Zhu, X., Bowe, D. D., Batra, A. K., Braun, T. P. & Marks, D. L., 2010, In: Endocrinology. 151, 2, p. 606-616 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leukemia Inhibitory Factor 100%
  • Appetite Depressants 99%
  • Pro-Opiomelanocortin 96%
  • Arcuate Nucleus of Hypothalamus 93%
  • Neurons 46%
  48 Scopus citations

• Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease

  Barazzoni, R., Zhu, X., Deboer, M., Datta, R., Culler, M. D., Zanetti, M., Guarnieri, G. & Marks, D. L., Jan 2010, In: Kidney International. 77, 1, p. 23-28 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ghrelin 100%
  • Chronic Renal Insufficiency 77%
  • Skeletal Muscle 66%
  • Eating 63%
  • Phosphorylation 57%
  49 Scopus citations

• Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure

  Scarlett, J. M., Bowe, D. D., Zhu, X., Batra, A. K., Grant, W. F. & Marks, D. L., Jul 2010, In: Journal of Endocrinology. 206, 1, p. 121-130 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Melanocortins 100%
  • Cachexia 85%
  • Rodentia 57%
  • Heart Failure 50%
  • Basal Metabolism 44%
  42 Scopus citations
• 2008

  Ghrelin treatment of chronic kidney disease: Improvements in lean body mass and cytokine profile

  DeBoer, M. D., Zhu, X., Levasseur, P. R., Inui, A., Hu, Z., Han, G., Mitch, W. E., Taylor, J. E., Halem, H. A., Dong, J. Z., Datta, R., Culler, M. D. & Marks, D. L., Feb 2008, In: Endocrinology. 149, 2, p. 827-835 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ghrelin 100%
  • Chronic Renal Insufficiency 77%
  • Cytokines 52%
  • Ghrelin Receptor 47%
  • Cachexia 41%
  129 Scopus citations