Gordon Mills

2015

Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients

Berg, A., Hoivik, E. A., Mjøs, S., Holst, F., Werner, H. M. J., Tangen, I. L., Taylor-Weiner, A., Gibson, W. J., Kusonmano, K., Wik, E., Trovik, J., Halle, M. K., Øyan, A. M., Kalland, K. H., Cherniack, A. D., Beroukhim, R., Stefansson, I., Mills, G. B., Krakstad, C. & Salvesen, H. B., 2015, In: Oncotarget. 6, 2, p. 1327-1339 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

Roy, A., Skibo, J., Kalume, F., Ni, J., Rankin, S., Lu, Y., Dobyns, W. B., Mills, G. B., Zhao, J. J., Baker, S. J. & Millen, K. J., Dec 3 2015, In: eLife. 4, DECEMBER2015, e12703.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing

Roy-Chowdhuri, S., De Melo Gagliato, D., Routbort, M. J., Patel, K. P., Singh, R. R., Broaddus, R., Lazar, A. J., Sahin, A., Alvarez, R. H., Moulder, S., Wheler, J. J., Janku, F., Gonzalez-Angulo, A. M., Chavez-MacGregor, M., Valero, V., Ueno, N. T., Mills, G., Mendelsohn, J., Yao, H., Aldape, K., & 2 othersLuthra, R. & Meric-Bernstam, F., Nov 2015, In: American journal of clinical pathology. 144, 5, p. 713-721 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance

Liang, J., Xu, Z. X., Ding, Z., Lu, Y., Yu, Q., Werle, K. D., Zhou, G., Park, Y. Y., Peng, G., Gambello, M. J. & Mills, G. B., Aug 14 2015, In: Nature communications. 6, 7926.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Scopus citations

Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure

Gong, L., Govan, J. M., Evans, E. B., Dai, H., Wang, E., Lee, S. W., Lin, H. K., Lazar, A. J., Mills, G. B. & Lin, S. Y., Jan 1 2015, In: Cell Cycle. 14, 14, p. 2323-2332 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

p85α neomorphic mutants: splitting away from the canonical path

Cheung, L. W. T. & Mills, G. B., Oct 2 2015, In: Molecular and Cellular Oncology. 2, 4, e983388.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer

Dillon, L. M., Bean, J. R., Yang, W., Shee, K., Symonds, L. K., Balko, J. M., McDonald, W. H., Liu, S., Gonzalez-Angulo, A. M., Mills, G. B., Arteaga, C. L. & Miller, T. W., Jul 23 2015, In: Oncogene. 34, 30, p. 3968-3976 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Scopus citations

Prognostic relevance of acquired uniparental disomy in serous ovarian cancer

Tuna, M., Ju, Z., Smid, M., Amos, C. I. & Mills, G. B., Feb 3 2015, In: Molecular Cancer. 14, 1, 29.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients

Westin, S. N., Ju, Z., Broaddus, R. R., Krakstad, C., Li, J., Pal, N., Lu, K. H., Coleman, R. L., Hennessy, B. T., Klempner, S. J., Werner, H. M. J., Salvesen, H. B., Cantley, L. C., Mills, G. B. & Myers, A. P., Oct 1 2015, In: Molecular Oncology. 9, 8, p. 1694-1703 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

Jeon, Y. J., Khelifa, S., Ratnikov, B., Scott, D. A., Feng, Y., Parisi, F., Ruller, C., Lau, E., Kim, H., Brill, L. M., Jiang, T., Rimm, D. L., Cardiff, R. D., Mills, G. B., Smith, J. W., Osterman, A. L., Kluger, Y. & Ronai, Z. A., Mar 9 2015, In: Cancer Cell. 27, 3, p. 354-369 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

169 Scopus citations

Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

Cheung, L. W. T., Walkiewicz, K. W., Besong, T. M., Guo, H., Hawke, D. H., Arold, S. T. & Mills, G. B., Jul 29 2015, In: eLife. 4, JULY 2015, e06866.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

RET fusion as a novel driver of medullary thyroid carcinoma

Grubbs, E. G., Ng, P. K. S., Bui, J., Busaidy, N. L., Chen, K., Lee, J. E., Lu, X., Lu, H., Meric-Bernstam, F., Mills, G. B., Palmer, G., Perrier, N. D., Scott, K. L., Shaw, K. R., Waguespack, S. G., Williams, M. D., Yelensky, R. & Cote, G. J., Mar 1 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 3, p. 788-793 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

Retrospective review of MET gene mutations

Zenali, M., DeKay, J., Liu, Z., Hamilton, S., Zuo, Z., Lu, X., Bakkar, R., Mills, G. & Broaddus, R., 2015, In: Oncoscience. 2, 5, p. 533-541 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Robust selection algorithm (RSA) for multi-omic biomarker discovery; integration with functional network analysis to identify miRNA regulated pathways in multiple cancers

Sehgal, V., Seviour, E. G., Moss, T. J., Mills, G. B., Azencott, R. & Ram, P. T., Oct 27 2015, In: PloS one. 10, 10, e0140072.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

SU2C phase Ib study of paclitaxel and MK-2206 in advanced solid tumors and metastatic breast cancer

Gonzalez-Angulo, A. M., Krop, I., Akcakanat, A., Chen, H., Liu, S., Li, Y., Culotta, K. S., Tarco, E., Piha-Paul, S., Moulder-Thompson, S., Velez-Bravo, V., Sahin, A. A., Doyle, L. A., Do, K. A., Winer, E. P., Mills, G. B., Kurzrock, R. & Meric-Bernstam, F., Mar 1 2015, In: Journal of the National Cancer Institute. 107, 3

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

Han, L., Diao, L., Yu, S., Xu, X., Li, J., Zhang, R., Yang, Y., Werner, H. M. J., Eterovic, A. K., Yuan, Y., Li, J., Nair, N., Minelli, R., Tsang, Y. H., Cheung, L. W. T., Jeong, K. J., Roszik, J., Ju, Z., Woodman, S. E., Lu, Y., & 4 othersScott, K. L., Li, J. B., Mills, G. B. & Liang, H., Oct 12 2015, In: Cancer Cell. 28, 4, p. 515-528 14 p., 2143.

Research output: Contribution to journal › Article › peer-review

Open Access

374 Scopus citations

The Molecular Taxonomy of Primary Prostate Cancer

Abeshouse, A., Ahn, J., Akbani, R., Ally, A., Amin, S., Andry, C. D., Annala, M., Aprikian, A., Armenia, J., Arora, A., Auman, J. T., Balasundaram, M., Balu, S., Barbieri, C. E., Bauer, T., Benz, C. C., Bergeron, A., Beroukhim, R., Berrios, M., Bivol, A., & 292 othersBodenheimer, T., Boice, L., Bootwalla, M. S., Borges Dos Reis, R., Boutros, P. C., Bowen, J., Bowlby, R., Boyd, J., Bradley, R. K., Breggia, A., Brimo, F., Bristow, C. A., Brooks, D., Broom, B. M., Bryce, A. H., Bubley, G., Burks, E., Butterfield, Y. S. N., Button, M., Canes, D., Carlotti, C. G., Carlsen, R., Carmel, M., Carroll, P. R., Carter, S. L., Cartun, R., Carver, B. S., Chan, J. M., Chang, M. T., Chen, Y., Cherniack, A. D., Chevalier, S., Chin, L., Cho, J., Chu, A., Chuah, E., Chudamani, S., Cibulskis, K., Ciriello, G., Clarke, A., Cooperberg, M. R., Corcoran, N. M., Costello, A. J., Cowan, J., Crain, D., Curley, E., David, K., Demchok, J. A., Demichelis, F., Dhalla, N., Dhir, R., Doueik, A., Drake, B., Dvinge, H., Dyakova, N., Felau, I., Ferguson, M. L., Frazer, S., Freedland, S., Fu, Y., Gabriel, S. B., Gao, J., Gardner, J., Gastier-Foster, J. M., Gehlenborg, N., Gerken, M., Gerstein, M. B., Getz, G., Godwin, A. K., Gopalan, A., Graefen, M., Graim, K., Gribbin, T., Guin, R., Gupta, M., Hadjipanayis, A., Haider, S., Hamel, L., Hayes, D. N., Heiman, D. I., Hess, J., Hoadley, K. A., Holbrook, A. H., Holt, R. A., Holway, A., Hovens, C. M., Hoyle, A. P., Huang, M., Hutter, C. M., Ittmann, M., Iype, L., Jefferys, S. R., Jones, C. D., Jones, S. J. M., Juhl, H., Kahles, A., Kane, C. J., Kasaian, K., Kerger, M., Khurana, E., Kim, J., Klein, R. J., Kucherlapati, R., Lacombe, L., Ladanyi, M., Lai, P. H., Laird, P. W., Lander, E. S., Latour, M., Lawrence, M. S., Lau, K., Lebien, T., Lee, D., Lee, S., Lehmann, K. V., Leraas, K. M., Leshchiner, I., Leung, R., Libertino, J. A., Lichtenberg, T. M., Lin, P., Linehan, W. M., Ling, S., Lippman, S. M., Liu, J., Liu, W., Lochovsky, L., Loda, M., Logothetis, C., Lolla, L., Longacre, T., Lu, Y., Luo, J., Ma, Y., Mahadeshwar, H. S., Mallery, D., Mariamidze, A., Marra, M. A., Mayo, M., McCall, S., McKercher, G., Meng, S., Mes-Masson, A. M., Merino, M. J., Meyerson, M., Mieczkowski, P. A., Mills, G. B., Shaw, K. R. M., Minner, S., Moinzadeh, A., Moore, R. A., Morris, S., Morrison, C., Mose, L. E., Mungall, A. J., Murray, B. A., Myers, J. B., Naresh, R., Nelson, J., Nelson, M. A., Nelson, P. S., Newton, Y., Noble, M. S., Noushmehr, H., Nykter, M., Pantazi, A., Parfenov, M., Park, P. J., Parker, J. S., Paulauskis, J., Penny, R., Perou, C. M., Piché, A., Pihl, T., Pinto, P. A., Prandi, D., Protopopov, A., Ramirez, N. C., Rao, A., Rathmell, W. K., Rätsch, G., Ren, X., Reuter, V. E., Reynolds, S. M., Rhie, S. K., Rieger-Christ, K., Roach, J., Robertson, A. G., Robinson, B., Rubin, M. A., Saad, F., Sadeghi, S., Saksena, G., Saller, C., Salner, A., Sanchez-Vega, F., Sander, C., Sandusky, G., Sauter, G., Sboner, A., Scardino, P. T., Scarlata, E., Schein, J. E., Schlomm, T., Schmidt, L. S., Schultz, N., Schumacher, S. E., Seidman, J., Neder, L., Seth, S., Sharp, A., Shelton, C., Shelton, T., Shen, H., Shen, R., Sherman, M., Sheth, M., Shi, Y., Shih, J., Shmulevich, I., Simko, J., Simon, R., Simons, J. V., Sipahimalani, P., Skelly, T., Sofia, H. J., Soloway, M. G., Song, X., Sorcini, A., Sougnez, C., Stepa, S., Stewart, C., Stewart, J., Stuart, J. M., Sullivan, T. B., Sun, C., Sun, H., Tam, A., Tan, D., Tang, J., Tarnuzzer, R., Tarvin, K., Taylor, B. S., Teebagy, P., Tenggara, I., Têtu, B., Tewari, A., Thiessen, N., Thompson, T., Thorne, L. B., Tirapelli, D. P., Tomlins, S. A., Trevisan, F. A., Troncoso, P., True, L. D., Tsourlakis, M. C., Tyekucheva, S., Van Allen, E., Van Den Berg, D. J., Veluvolu, U., Verhaak, R., Vocke, C. D., Voet, D., Wan, Y., Wang, Q., Wang, W., Wang, Z., Weinhold, N., Weinstein, J. N., Weisenberger, D. J., Wilkerson, M. D., Wise, L., Witte, J., Wu, C. C., Wu, J., Wu, Y., Xu, A. W., Yadav, S. S., Yang, L., Yang, L., Yau, C., Ye, H., Yena, P., Zeng, T., Zenklusen, J. C., Zhang, H., Zhang, J., Zhang, J., Zhang, W., Zhong, Y., Zhu, K. & Zmuda, E., Nov 5 2015, In: Cell. 163, 4, p. 1011-1025 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2127 Scopus citations

α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration

Boggs, A. E., Vitolo, M. I., Whipple, R. A., Charpentier, M. S., Goloubeva, O. G., Ioffe, O. B., Tuttle, K. C., Slovic, J., Lu, Y., Mills, G. B. & Martin, S. S., Jan 1 2015, In: Cancer Research. 75, 1, p. 203-215 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

140 Scopus citations

2014

A Bayesian hierarchical model for inference across related reverse phase protein arrays experiments

Mitra, R., Müller, P., Ji, Y., Zhu, Y., Mills, G. & Lu, Y., Nov 2 2014, In: Journal of Applied Statistics. 41, 11, p. 2483-2492 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A comprehensive comparison of normalization methods for loading control and variance stabilization of reverse-phase protein array data

Liu, W., Ju, Z., Lu, Y., Mills, G. B. & Akbani, R., Oct 16 2014, In: Cancer Informatics. 13, p. 109-117 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma

Mazumdar, T., Byers, L. A., Ng, P. K. S., Mills, G. B., Peng, S., Diao, L., Fan, Y. H., Stemke-Hale, K., Heymach, J. V., Myers, J. N., Glisson, B. S. & Johnson, F. M., Nov 1 2014, In: Molecular cancer therapeutics. 13, 11, p. 2738-2750 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer

Jeong, W., Kim, S. B., Sohn, B. H., Park, Y. Y., Park, E. S., Kim, S. C., Kim, S. S., Johnson, R. L., Birrer, M., Bowtell, D. S. L., Mills, G. B., Sood, A. & Lee, J. S., Feb 1 2014, In: Anticancer research. 34, 2, p. 811-818 8 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

A curated census of autophagy-modulating proteins and small molecules: Candidate targets for cancer therapy

Lorenzi, P. L., Claerhout, S., Mills, G. B. & Weinstein, J. N., Jul 2014, In: Autophagy. 10, 7, p. 1316-1326 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer

Hu, X., Feng, Y., Zhang, D., Zhao, S. D., Hu, Z., Greshock, J., Zhang, Y., Yang, L., Zhong, X., Wang, L. P., Jean, S., Li, C., Huang, Q., Katsaros, D., Montone, K. T., Tanyi, J. L., Lu, Y., Boyd, J., Nathanson, K. L., Li, H., & 2 othersMills, G. B. & Zhang, L., 2014, In: Cancer Cell. 26, 3, p. 344-357 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

329 Scopus citations

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: Protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

Wiegand, K. C., Hennessy, B. T., Leung, S., Wang, Y., Ju, Z., McGahren, M., Kalloger, S. E., Finlayson, S., Stemke-Hale, K., Lu, Y., Zhang, F., Anglesio, M. S., Gilks, B., Mills, G. B., Huntsman, D. G. & Carey, M. S., Feb 22 2014, In: BMC cancer. 14, 1, 120.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

A genetic mouse model of invasive endometrial cancer driven by concurrent loss of pten and Lkb1 is highly responsive to mTOR inhibition

Cheng, H., Liu, P., Zhang, F., Xu, E., Symonds, L., Ohlson, C. E., Bronson, R. T., Maira, S. M., Tomaso, E. D., Li, J., Myers, A. P., Cantley, L. C., Mills, G. B. & Zhao, J. J., Jan 1 2014, In: Cancer Research. 74, 1, p. 15-23 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

AKT pathway genes define 5 prognostic subgroups in glioblastoma

Joy, A., Ramesh, A., Smirnov, I., Reiser, M., Misra, A., Shapiro, W. R., Mills, G. B., Kim, S. & Feuerstein, B. G., Jul 1 2014, In: PloS one. 9, 7, e100827.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation

Wolf, J., Müller-Decker, K., Flechtenmacher, C., Zhang, F., Shahmoradgoli, M., Mills, G. B., Hoheisel, J. D. & Boettcher, M., Aug 14 2014, In: Oncogene. 33, 33, p. 4273-4278 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

A pan-cancer proteomic perspective on the cancer genome atlas

Akbani, R., Ng, P. K. S., Werner, H. M. J., Shahmoradgoli, M., Zhang, F., Ju, Z., Liu, W., Yang, J. Y., Yoshihara, K., Li, J., Ling, S., Seviour, E. G., Ram, P. T., Minna, J. D., Diao, L., Tong, P., Heymach, J. V., Hill, S. M., Dondelinger, F., Städler, N., & 9 othersByers, L. A., Meric-Bernstam, F., Weinstein, J. N., Broom, B. M., Verhaak, R. G. W., Liang, H., Mukherjee, S., Lu, Y. & Mills, G. B., May 29 2014, In: Nature communications. 5, 3887.

Research output: Contribution to journal › Article › peer-review

Open Access

406 Scopus citations

Assessing the clinical utility of cancer genomic and proteomic data across tumor types

Yuan, Y., Van Allen, E. M., Omberg, L., Wagle, N., Amin-Mansour, A., Sokolov, A., Byers, L. A., Xu, Y., Hess, K. R., Diao, L., Han, L., Huang, X., Lawrence, M. S., Weinstein, J. N., Stuart, J. M., Mills, G. B., Garraway, L. A., Margolin, A. A., Getz, G. & Liang, H., Jul 2014, In: Nature biotechnology. 32, 7, p. 644-652 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

220 Scopus citations

Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival

Pande, M., Bondy, M. L., Do, K. A., Sahin, A. A., Ying, J., Mills, G. B., Thompson, P. A. & Brewster, A. M., Sep 1 2014, In: Breast Cancer Research and Treatment. 147, 2, p. 381-387 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Bias from removing read duplication in ultra-deep sequencing experiments

Zhou, W., Chen, T., Zhao, H., Eterovic, A. K., Meric-Bernstam, F., Mills, G. B. & Chen, K., 2014, In: Bioinformatics. 30, 8, p. 1073-1080 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors

Hassan, B., Akcakanat, A., Sangai, T., Evans, K. W., Adkins, F., Eterovic, A. K., Zhao, H., Chen, K., Chen, H., Do, K. A., Xie, S. M., Holder, A. M., Naing, A., Mills, G. B. & Meric-Bernstam, F., 2014, In: Oncotarget. 5, 18, p. 8544-8557 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma

Liu, Y., Patel, L., Mills, G. B., Lu, K. H., Sood, A. K., Ding, L., Kucherlapati, R., Mardis, E. R., Levine, D. A., Shmulevich, I., Broaddus, R. R. & Zhang, W., Sep 1 2014, In: Journal of the National Cancer Institute. 106, 9

Research output: Contribution to journal › Article › peer-review

Open Access

167 Scopus citations

cMET activation and EGFR-directed therapy resistance in triple-negative breast cancer

Sohn, J., Liu, S., Parinyanitikul, N., Lee, J., Hort obagyi, G. N., Mills, G. B., Ueno, N. T. & Gonzalez-Angulo, A. M., 2014, In: Journal of Cancer. 5, 9, p. 745-753 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Comprehensive molecular characterization of gastric adenocarcinoma

Cancer Genome Atlas Research Network, Sep 11 2014, In: Nature. 513, 7517, p. 202-209 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4556 Scopus citations

Comprehensive molecular characterization of urothelial bladder carcinoma

Weinstein, J. N., Akbani, R., Broom, B. M., Wang, W., Verhaak, R. G. W., McConkey, D., Lerner, S., Morgan, M., Creighton, C. J., Smith, C., Cherniack, A. D., Kim, J., Pedamallu, C. S., Noble, M. S., Al-Ahmadie, H. A., Reuter, V. E., Rosenberg, J. E., F.Bajorin, D., Bochner, B. H., Solit, D. B., & 273 othersKoppie, T., Robinson, B., Gordenin, D. A., Fargo, D., Klimczak, L. J., Roberts, S. A., Au, J., Laird, P. W., Hinoue, T., Schultz, N., Ramirez, R., Hansel, D., Hoadley, K. A., Kim, W. Y., Damrauer, J. S., Baylin, S. B., Mungall, A. J., Robertson, A. G., Chu, A., Kwiatkowski, D. J., Sougnez, C., Cibulskis, K., Lichtenstein, L., Sivachenko, A., Stewart, C., Lawrence, M. S., Getz, G., Lander, E., Gabrie, S. B., Donehower, L., Carter, S. L., Saksena, G., Schumacher, S. E., Freeman, S. S., Jung, J., Bhatt, A. S., Pugh, T., Beroukhim, R., Meyerson, M., Ally, A., Balasundaram, M., Butterfield, Y. S. N., Dhalla, N., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Wong, T., Wye, N., Bowlby, R., Chuah, E., Guin, R., Shen, H., Bootwalla, M. S., Triche, T., Lai, P. H., Van Den Berg, D. J., Weisenberger, D. J., Balu, S., Bodenheimer, T., Hoyle, A. P., Jefferys, S. R., Meng, S., Mose, L. E., Simons, J. V., Soloway, M. G., Wu, J., Parker, J. S., Hayes, D. N., Roach, J., Buda, E., Jones, C. D., Mieczkowski, P. A., Tan, D., Veluvolu, U., Waring, S., Auman, J. T., Perou, C. M., Wilkerson, M. D., Santoso, N., Parfenov, M., Ren, X., Pantazi, A., Hadjipanayis, A., Seidman, J., Kucherlapati, R., Lee, S., Yang, L., Park, P. J., Xu, A. W., Protopopov, A., Zhang, J., Bristow, C., Mahadeshwar, H. S., Seth, S., Song, X., Tang, J., Zeng, D., Chin, L., Guo, C., Casasent, T. D., Liu, W., Ju, Z., Motter, T., Peng, B., Ryan, M., Su, X., Yang, J. Y., Lorenzi, P. L., Yao, H., Zhang, N., Zhang, J., Mills, G. B., Cho, J., DiCara, D., Frazer, S., Gehlenborg, N., Heiman, D. I., Lin, P., Liu, Y., Stojanov, P., Voet, D., Zhang, H., Zou, L., Bernard, B., Kreisberg, D., Reynolds, S., Rovira, H., Shmulevich, I., Gao, J., Jacobsen, A., Aksoy, B. A., Antipin, Y., Ciriello, G., Dresdner, G., Gross, B., Lee, W., Reva, B., Shen, R., Sinha, R., Sumer, S. O., Weinhold, N., Ladanyi, M., Sander, C., Benz, C., Carlin, D., Haussler, D., Ng, S., Paull, E., Stuart, J., Zhu, J., Liu, Y., Zhang, W., Taylor, B. S., Lichtenberg, T. M., Zmuda, E., Barr, T., Black, A. D., George, M., Hanf, B., Helsel, C., McAllister, C., Ramirez, N. C., Tabler, T. R., Weaver, S., Wise, L., Bowen, J., Gastier-Foster, J. M., Jian, W., Tello, S., Ittman, M., Castro, P., McClenden, W. D., Gibbs, R., Saller, C., Tarvin, K., DiPiero, J. M., Owens, J., Bollag, R., Li, Q., Weinberger, P., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Swanson, P., Shelton, T., Curley, E., Gardner, J., Mallery, D., Penny, R., Van Bang, N., Hanh, P. T., Kohl, B., Van Le, X., Phu, B. D., Thorp, R., Tien, N. V., Vinh, L. Q., Sandusky, G., Burks, E., Christ, K., Gee, J., Holway, A., Moinzadeh, A., Sorcini, A., Sullivan, T., Garcia-Grossman, I. R., Regazzi, A. M., Boice, L., Rathmell, W. K., Thorne, L., Bastacky, S., Davies, B., Dhir, R., Gingrich, J., Hrebinko, R., Maranchie, J., Nelson, J., Parwani, A., Bshara, W., Gaudioso, C., Morrison, C., Alexopoulou, V., Bartlett, J., Engel, J., Kodeeswaran, S., Antic, T., O'Donnell, P. H., Smith, N. D., Steinberg, G. D., Egea, S., Gomez-Fernandez, C., Herbert, L., Jorda, M., Soloway, M., Beaver, A., Carter, S., Kapur, P., Lewis, C., Lotan, Y., Bondaruk, J., Czerniak, B., Skinner, E., Aldape, K., Jensen, M. A., Kahn, A. B., Pihl, T. D., Pot, D. A., Srinivasan, D., Wan, Y., Ferguson, M. L., Zenklusen, J. C., Davidsen, T., Demchok, J. A., Shaw, K. R. M., Sheth, M., Tarnuzzer, R., Wang, Z., Yang, L., Hutter, C., Ozenberger, B. A., Sofia, H. J. & Eley, G., 2014, In: Nature. 507, 7492, p. 315-322 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2310 Scopus citations

Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network

Collisson, E. A., Campbell, J. D., Brooks, A. N., Berger, A. H., Lee, W., Chmielecki, J., Beer, D. G., Cope, L., Creighton, C. J., Danilova, L., Ding, L., Getz, G., Hammerman, P. S., Hayes, D. N., Hernandez, B., Herman, J. G., Heymach, J. V., Jurisica, I., Kucherlapati, R., Kwiatkowski, D., & 290 othersLadanyi, M., Robertson, G., Schultz, N., Shen, R., Sinha, R., Sougnez, C., Tsao, M. S., Travis, W. D., Weinstein, J. N., Wigle, D. A., Wilkerson, M. D., Chu, A., Cherniack, A. D., Hadjipanayis, A., Rosenberg, M., Weisenberger, D. J., Laird, P. W., Radenbaugh, A., Ma, S., Stuart, J. M., Byers, L. A., Baylin, S. B., Govindan, R., Meyerson, M., Gabriel, S. B., Cibulskis, K., Kim, J., Stewart, C., Lichtenstein, L., Lander, E. S., Lawrence, M. S., Getz, E., Fulton, R., Fulton, L. L., McLellan, M. D., Wilson, R. K., Ye, K., Fronick, C. C., Maher, C. A., Miller, C. A., Wendl, M. C., Cabanski, C., Mardis, E., Wheeler, D., Balasundaram, M., Butterfield, Y. S. N., Carlsen, R., Chuah, E., Dhalla, N., Guin, R., Hirst, C., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, A. J., Schein, J. E., Sipahimalani, P., Tam, A., Varhol, R., Robertson, A. G., Wye, N., Thiessen, N., Holt, R. A., Jones, S. J. M., Marra, M. A., Imielinski, M., Onofrio, R. C., Hodis, E., Zack, T., Helman, E., Pedamallu, C. S., Mesirov, J., Saksena, G., Schumacher, S. E., Carter, S. L., Garraway, L., Beroukhim, R., Lee, S., Mahadeshwar, H. S., Pantazi, A., Protopopov, A., Ren, X., Seth, S., Song, X., Tang, J., Yang, L., Zhang, J., Chen, P. C., Parfenov, M., Xu, A. W., Santoso, N., Chin, L., Park, P. J., Hoadley, K. A., Auman, J. T., Meng, S., Shi, Y., Buda, E., Waring, S., Veluvolu, U., Tan, D., Mieczkowski, P. A., Jones, C. D., Simons, J. V., Soloway, M. G., Bodenheimer, T., Jefferys, S. R., Roach, J., Hoyle, A. P., Wu, J., Balu, S., Singh, D., Prins, J. F., Marron, J. S., Parker, J. S., Perou, C. M., Liu, J., Maglinte, D. T., Lai, P. H., Bootwalla, M. S., Van Den Berg, D. J., Triche, T., Cho, J., DiCara, D., Heiman, D., Lin, P., Mallard, W., Voet, D., Zhang, H., Zou, L., Noble, M. S., Gehlenborg, N., Thorvaldsdottir, H., Nazaire, M. D., Robinson, J., Aksoy, B. A., Ciriello, G., Taylor, B. S., Dresdner, G., Gao, J., Gross, B., Seshan, V. E., Reva, B., Sumer, S. O., Weinhold, N., Sander, C., Ng, S., Zhu, J., Benz, C. C., Yau, C., Haussler, D., Spellman, P. T., Kimes, P. K., Broom, B. M., Wang, J., Lu, Y., Ng, P. K. S., Diao, L., Liu, W., Amos, C. I., Akbani, R., Mills, G. B., Curley, E., Paulauskis, J., Lau, K., Morris, S., Shelton, T., Mallery, D., Gardner, J., Penny, R., Saller, C., Tarvin, K., Richards, W. G., Cerfolio, R., Bryant, A., Raymond, D. P., Pennell, N. A., Farver, C., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Brown, J., Bauer, T., Dolzhanskiy, C. O., Potapova, O., Rotin, D., Voronina, O., Nemirovich-Danchenko, E., Fedosenko, K. V., Gal, A., Behera, M., Ramalingam, S. S., Sica, G., Flieder, D., Boyd, J., Weaver, J. E., Kohl, B., Thinh, D. H. Q., Sandusky, G., Juhl, H., Duhig, E., Illei, P., Gabrielson, E., Shin, J., Lee, B., Rogers, K., Trusty, D., Brock, M. V., Williamson, C., Burks, E., Rieger-Christ, K., Holway, A., Sullivan, T., Asiedu, M. K., Kosari, F., Rekhtman, N., Zakowski, M., Rusch, V. W., Zippile, P., Suh, J., Pass, H., Goparaju, C., Owusu-Sarpong, Y., Bartlett, J. M. S., Kodeeswaran, S., Parfitt, J., Sekhon, H., Albert, M., Eckman, J., Myers, J. B., Morrison, C., Gaudioso, C., Borgia, J. A., Bonomi, P., Pool, M., Liptay, M. J., Moiseenko, F., Zaytseva, I., Dienemann, H., Meister, M., Schnabel, P. A., Muley, T. R., Peifer, M., Gomez-Fernandez, C., Herbert, L., Egea, S., Huang, M., Thorne, L. B., Boice, L., Salazar, A. H., Funkhouser, W. K., Rathmell, W. K., Dhir, R., Yousem, S. A., Dacic, S., Schneider, F., Siegfried, J. M., Hajek, R., Watson, M. A., McDonald, S., Meyers, B., Clarke, B., Yang, I. A., Fong, K. M., Hunter, L., Windsor, M., Bowman, R. V., Peters, S., Letovanec, I., Khan, K. Z., Jensen, M. A., Snyder, E. E., Srinivasan, D., Kahn, A. B., Baboud, J., Pot, D. A., Shaw, K. R. M., Sheth, M., Davidsen, T., Demchok, J. A., Yang, L., Wang, Z., Tarnuzzer, R., Zenklusen, J. C., Ozenberger, B. A., Sofia, H. J. & Cheney, R., 2014, In: Nature. 511, 7511, p. 543-550 8 p.

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Open Access

3981 Scopus citations

Concordance of genomic alterations between primary and recurrent breast cancer

Meric-Bernstam, F., Frampton, G. M., Ferrer-Lozano, J., Yelensky, R., Pérez-Fidalgo, J. A., Wang, Y., Palmer, G. A., Ross, J. S., Miller, V. A., Su, X., Eroles, P., Barrera, J. A., Burgues, O., Lluch, A. M., Zheng, X., Sahin, A., Stephens, P. J., Mills, G. B., Cronin, M. T. & Gonzalez-Angulo, A. M., May 2014, In: Molecular cancer therapeutics. 13, 5, p. 1382-1389 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules

Guo, H., Gao, M., Lu, Y., Liang, J., Lorenzi, P. L., Bai, S., Hawke, D. H., Li, J., Dogruluk, T., Scott, K. L., Jonasch, E., Mills, G. B. & Ding, Z., Jun 26 2014, In: Oncogene. 33, 26, p. 3463-3472 10 p.

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Open Access

35 Scopus citations

Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers

Chaluvally-Raghavan, P., Zhang, F., Pradeep, S., Hamilton, M. P., Zhao, X., Rupaimoole, R., Moss, T., Lu, Y., Yu, S., Pecot, C. V., Aure, M. R., Peuget, S., Rodriguez-Aguayo, C., Han, H. D., Zhang, D., Venkatanarayan, A., Krohn, M., Kristensen, V. N., Gagea, M., Ram, P., & 11 othersLiu, W., Lopez-Berestein, G., Lorenzi, P. L., Børresen-Dale, A. L., Chin, K., Gray, J., Dusetti, N. J., McGuire, S. E., Flores, E. R., Sood, A. K. & Mills, G. B., Dec 8 2014, In: Cancer Cell. 26, 6, p. 863-879 17 p.

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Open Access

44 Scopus citations

Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancer

Hsu, Y. H., Yao, J., Chan, L. C., Wu, T. J., Hsu, J. L., Fang, Y. F., Wei, Y., Wu, Y., Huang, W. C., Liu, C. L., Chang, Y. C., Wang, M. Y., Li, C. W., Shen, J., Chen, M. K., Sahin, A. A., Sood, A., Mills, G. B., Yu, D., Hortobagyi, G. N., & 1 othersHung, M. C., Sep 1 2014, In: Cancer Research. 74, 17, p. 4822-4835 14 p.

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Open Access

57 Scopus citations

Differences in gene and protein expression and the effects of race/ethnicity on breast cancer subtypes

Chavez-MacGregor, M., Liu, S., De Melo-Gagliato, D., Chen, H., Do, K. A., Pusztai, L., Symmans, W. F., Nair, L., Hortobagyi, G. N., Mills, G. B., Meric-Bernstam, F. & Gonzalez-Angulo, A. M., Feb 2014, In: Cancer Epidemiology Biomarkers and Prevention. 23, 2, p. 316-323 8 p.

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Open Access

16 Scopus citations

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

Lui, V. W. Y., Peyser, N. D., Ng, P. K. S., Hritz, J., Zeng, Y., Lu, Y., Li, H., Wang, L., Gilbert, B. R., General, I. J., Bahar, I., Ju, Z., Wang, Z., Pendleton, K. P., Xiao, X., Du, Y., Vries, J. K., Hammerman, P. S., Garraway, L. A., Mills, G. B., & 2 othersJohnson, D. E. & Grandis, J. R., Jan 21 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1114-1119 6 p.

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Open Access

77 Scopus citations

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

Zhou, G., Wang, J., Zhao, M., Xie, T. X., Tanaka, N., Sano, D., Patel, A. A., Ward, A. M., Sandulache, V. C., Jasser, S. A., Skinner, H. D., Fitzgerald, A. L., Osman, A. A., Wei, Y., Xia, X., Songyang, Z., Mills, G. B., Hung, M. C., Caulin, C., Liang, J., & 1 othersMyers, J. N., Jun 19 2014, In: Molecular Cell. 54, 6, p. 960-974 15 p.

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Open Access

187 Scopus citations

Genetic and pharmacological strategies to refunctionalize the von hippel lindau R167Q mutant protein

Ding, Z., German, P., Bai, S., Reddy, A. S., Liu, X. D., Sun, M., Zhou, L., Chen, X., Zhao, X., Wu, C., Zhang, S., Mills, G. B. & Jonasch, E., Jun 1 2014, In: Cancer Research. 74, 11, p. 3127-3136 10 p.

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Open Access

18 Scopus citations

Genome-wide transcriptome profiling of homologous recombination DNA repair

Peng, G., Lin, C. C. J., Mo, W., Dai, H., Park, Y. Y., Kim, S. M., Peng, Y., Mo, Q., Siwko, S., Hu, R., Lee, J. S., Hennessy, B., Hanash, S., Mills, G. B. & Lin, S. Y., Feb 20 2014, In: Nature communications. 5, 3361.

Research output: Contribution to journal › Article › peer-review

Open Access

167 Scopus citations

Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer

Liu, Y., Zhou, R., Baumbusch, L. O., Tsavachidis, S., Brewster, A. M., Do, K. A., Sahin, A., Hortobagyi, G. N., Taube, J. H., Mani, S. A., Aarøe, J., Wärnberg, F., Børresen-Dale, A. L., Mills, G. B., Thompson, P. A. & Bondy, M. L., Jan 2014, In: Breast Cancer Research and Treatment. 143, 1, p. 189-201 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Implementation of biomarker-driven cancer therapy: Existing tools and remaining gaps

Bailey, A. M., Mao, Y., Zeng, J., Holla, V., Johnson, A., Brusco, L., Chen, K., Mendelsohn, J., Routbort, M. J., Mills, G. B. & Meric-Bernstam, F., Feb 2014, In: Discovery Medicine. 17, 92, p. 101-114 14 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Influence of biospecimen variables on proteomic biomarkers in breast cancer

Meric-Bernstam, F., Akcakanat, A., Chen, H., Sahin, A., Tarco, E., Carkaci, S., Adrada, B. E., Singh, G., Do, K. A., Garces, Z. M., Mittendorf, E., Babiera, G., Bedrosian, I., Hwang, R., Krishnamurthy, S., Symmans, W. F., Gonzalez-Angulo, A. M. & Mills, G. B., Jul 15 2014, In: Clinical Cancer Research. 20, 14, p. 3870-3883 14 p.

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Open Access

42 Scopus citations

Gordon Mills

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